56-18-8

Usage

Chemical Properties

colourless to yellow liquid

Uses

Different sources of media describe the Uses of 56-18-8 differently. You can refer to the following data:
1. A structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.
2. Bis(3-aminopropyl)amine (BAPA) can be used:To synthesize chitosan based hydrogels having potential biomedical applications.For the functionalization of nanoparticles to yield terminal ?NH2 groups for further modifications. As an internal dispersing agent for the synthesis of water-dispersible polyurethanes.As a ligand in the preparation of [Cu(bapa)]2[Mo(CN)8]·7H2O photomagnetic coordination polymer.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 3736, 1993 DOI: 10.1021/jo00066a028Journal of the American Chemical Society, 105, p. 5002, 1983 DOI: 10.1021/ja00353a025

General Description

A colorless liquid. Less dense than water. Flash point of 170°F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.

Air & Water Reactions

Water soluble.

Reactivity Profile

DIPROPYLENETRIAMINE neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. DIPROPYLENETRIAMINE can react with oxidizing materials .

Hazard

Toxic by ingestion and inhalation; irritant.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by skin contact. Moderately toxic by ingestion. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NO,. An explosive

Purification Methods

Dry the amine with Na and distil it under vacuum. [Beilstein 4 IV 1278.]

Synthetic route

azetidine (503-29-7) + Trimethylenediamine (109-76-2) → bis(3-aminopropyl)amine (56-18-8) + N-γ-aminopropyltrimethyleneimine (54262-75-8)

Conditions	Yield
palladium at 170℃;	A 84% B 1%
palladium Product distribution;

3,3'-Iminodipropionitrile (111-94-4) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With sodium hydroxide; hydrogen; nickel In ethanol under 2068.6 Torr;	81%
With sodium hydroxide; sodium tetrahydroborate; nickel In methanol at 50℃; for 0.5h;	80%
With sodium-potassium alloy; butan-1-ol
With ammonia; nickel at 90 - 125℃; under 36775.4 - 183877 Torr; Hydrogenation;

{Cutn2}(ClO4)2 → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With nitrogen(II) oxide In acetonitrile	55%

1,3-Dichloropropane (142-28-9) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ethanol; ammonia; water

1,3-dibromo-propane (109-64-8) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ammonia

N1-(cyanoethyl)-1,3-propanediamine (35513-93-0) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ammonia; hydrogen; nickel In ethanol

3,3',3''-nitrilotripropanamide (2664-61-1) → bis(3-aminopropyl)amine (56-18-8) + Tris(3-aminopropyl)amine (4963-47-7)

Conditions	Yield
With lithium aluminium tetrahydride

N-γ-aminopropyltrimethyleneimine (54262-75-8) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ammonia at 120℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.);;
With ammonium hydroxide at 50℃; Rate constant; Thermodynamic data; E(a);

3-chloropropan-1-amine (14753-26-5) + Trimethylenediamine (109-76-2) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ammonium hydroxide at 50℃; Rate constant; Thermodynamic data; E(a);

trimethyleneglycol (504-63-2) → bis(3-aminopropyl)amine (56-18-8) + propan-1-ol (71-23-8) + Trimethylenediamine (109-76-2) + propan-1-ol-3-amine (156-87-6)

Conditions	Yield
With ammonia; hydrogen; carbon monoxide at 210℃; under 101258 Torr; Product distribution; Further Variations:; Catalysts; Temperatures; Pressures; amination;

ammonia (7664-41-7) + 1,3-dibromo-propane (109-64-8) → bis(3-aminopropyl)amine (56-18-8) + Trimethylenediamine (109-76-2)

Conditions	Yield
at 25℃;

bis-<3-bromo-propyl>-amine → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With ammonia

3,3'-Iminodipropionitrile (111-94-4) + ammonia (7664-41-7) + Raney nickel → bis(3-aminopropyl)amine (56-18-8) + Tris(3-aminopropyl)amine (4963-47-7) + Trimethylenediamine (109-76-2)

Conditions	Yield
at 90 - 125℃; unter Druck;

ammonia (7664-41-7) + bis-(3-bromo-propyl)-amine; hydrobromide → bis(3-aminopropyl)amine (56-18-8)

Trimethylenediamine (109-76-2) → bis(3-aminopropyl)amine (56-18-8) + N,N'-bis-(3-aminopropyl)-1,3-propanediamine (4605-14-5) + N-(3-aminopropyl)-N'-<3-<(3-aminopropyl)amino>propyl>propane-1,3-diamine (13274-42-5)

Conditions	Yield
With hydrogen at 100 - 200℃; under 0 - 15001.5 Torr; Product distribution / selectivity;

bis-(3-amino-propyl)-carbamic acid tert-butyl ester (167568-21-0) → bis(3-aminopropyl)amine (56-18-8)

Conditions	Yield
With trifluoroacetic acid at 20℃; Inert atmosphere;

ethylenediamine (107-15-3) + Trimethylenediamine (109-76-2) → bis(3-aminopropyl)amine (56-18-8) + tripropylene-tetramine (349636-04-0) + N-(2-Aminoethyl)-1,3-propanediamine (13531-52-7) + N-(2-aminoethyl)dipropylenetriamine

Conditions	Yield
With hydrogen; Ni and Re on Al2O3/SiO2 at 130 - 135℃; under 8517.48 Torr; for 6h; Autoclave;

dipropylenetriamine NONOate (146724-95-0) → bis(3-aminopropyl)amine (56-18-8) + nitrogen(II) oxide (10102-43-9)

Conditions	Yield
With perchloric acid In water at 25℃; pH=< 2; Kinetics; pH-value;

bis(3-aminopropyl)amine (56-18-8) + phthalic anhydride (85-44-9) → N,N-bis(phthalimidopropyl)amine (102202-87-9)

Conditions	Yield
In acetic acid for 1h; Heating;	100%
	99%
With acetic acid for 2h; Reflux;	98%

bis(3-aminopropyl)amine (56-18-8) + ethyl trifluoroacetate, (383-63-1) → N-[3-(trifluoroacetamido)propyl]-N'-trifluoroacetyl-1,3-diaminopropane (252334-20-6)

Conditions	Yield
In ethanol for 60h; Acylation;	100%
In acetonitrile at 20℃; for 15h;	100%
In tetrahydrofuran Acylation; Heating;	99%

(3α,5β)-3,24-bis(3-bromophenoxy)cholane (874306-28-2) + bis(3-aminopropyl)amine (56-18-8) → N-(3-Amino-propyl)-N'-{3-[(R)-4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-{3-[3-(3-amino-propylamino)-propylamino]-phenoxy}-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentyloxy]-phenyl}-propane-1,3-diamine

Conditions	Yield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane Heating;	100%
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; [Pd(dibenzylideneacetone)2] In 1,4-dioxane for 5h; Heating;	90 % Spectr.

bis(3-aminopropyl)amine (56-18-8) + 2,2-dimethyltetrahydro-[1,3]dithiol[4,5-c]furan (55550-98-6) → C20H33N3O6S4 (869193-26-0)

Conditions	Yield
In dichloromethane at 0 - 20℃; for 1h;	100%

bis(3-aminopropyl)amine (56-18-8) + tris(dimethylamino)borane (4375-83-1) → 1,8,10,9-Triazoboradecalin (1730-15-0)

Conditions	Yield
	100%
In benzene byproducts: dimethylamine; reflux, 1h;	75%
In benzene byproducts: dimethylamine; reflux, 1h;	75%

bis(3-aminopropyl)amine (56-18-8) + acrylonitrile (107-13-1) → 3-[{3-[{3-[bis-(2-cyanoethyl)amino]propyl}-(2-cyanoethyl)amino]propyl}-(2-cyanoethyl)amino]propionitrile (1155879-59-6)

Conditions	Yield
at 20℃; for 120h; Michael condensation;	100%
In water at 20 - 110℃; Inert atmosphere;	63%

bis(3-aminopropyl)amine (56-18-8) + carbonic acid dimethyl ester (616-38-6) → C10H21N3O4 (121138-98-5)

Conditions	Yield
at 20℃; under 750075 Torr; for 16h; neat (no solvent);	100%

bis(3-aminopropyl)amine (56-18-8) + 2-methyl-2-(methyltellanyl)propanoic acid → C16H33N3O2Te2

Conditions	Yield
Stage #1: 2-methyl-2-(methyltellanyl)propanoic acid With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: bis(3-aminopropyl)amine In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;	100%

bis(3-aminopropyl)amine (56-18-8) + 2,6-Pyridinedicarboxaldehyde (5431-44-7) + zinc perchlorate → C19H35N7Zn(2+)*2ClO4(1-)

Conditions	Yield
Stage #1: 2,6-Pyridinedicarboxaldehyde; zinc perchlorate In methanol at 25℃; for 1.5h; Stage #2: bis(3-aminopropyl)amine In methanol at 25℃; for 12h;	100%

pyridine-2-carbaldehyde (1121-60-4) + bis(3-aminopropyl)amine (56-18-8) → N-pyridin-2-ylmethyl-N'-{3-[(pyridin-2-ylmethyl)amino]propyl}propane-1,3-diamine (64739-67-9)

Conditions	Yield
Stage #1: pyridine-2-carbaldehyde; bis(3-aminopropyl)amine With acetic acid; zinc In methanol at 70 - 80℃; for 4.5h; Stage #2: With hydrogenchloride In methanol at 20℃; Stage #3: With sodium hydroxide In water	99%

bis(3-aminopropyl)amine (56-18-8) + 2-acetyldimedone (1755-15-3) → N1,N9-bis-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-norspermidine (674297-98-4)

Conditions	Yield
In ethanol for 2h; Heating;	99%

bis(3-aminopropyl)amine (56-18-8) + 2-bromonaphthalene (580-13-2) → N1-(3-aminopropyl)-N3-(naphthalen-2-yl)propane-1,3-diamine (1351684-37-1)

Conditions	Yield
With copper(l) iodide; caesium carbonate; rac-Pro-OH In acetonitrile for 24h; Ullmann reaction; Inert atmosphere; Reflux; regioselective reaction;	99%
With copper(l) iodide; caesium carbonate; L-proline In acetonitrile Inert atmosphere; Reflux;	90%

bis(3-aminopropyl)amine (56-18-8) + 1,2-bis(4-tert-butyl-2,6-diformylphenylsulfanyl)ethane (255367-21-6) → C38H64N6S2 (1417170-21-8)

Conditions	Yield
Stage #1: bis(3-aminopropyl)amine; 1,2-bis(4-tert-butyl-2,6-diformylphenylsulfanyl)ethane In ethanol; dichloromethane at 0 - 20℃; for 23h; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 4h;	99%

bis(3-aminopropyl)amine (56-18-8) + tetradecane-1,14-diol dimesylate (193215-78-0) → N,N'-Bis-[3-(3-amino-propylamino)-propyl]-tetradecane-1,14-diamine

Conditions	Yield
In acetonitrile for 4h; Heating;	98%

1-(benzyloxy)-6-(2-thioxothiazolidine-3-carbonyl)pyridin-2(1H)-one (770738-07-3) + bis(3-aminopropyl)amine (56-18-8) → N,N'-(azanediylbis(propane-3,1-diyl))bis(1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxamide)

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	98%
With triethylamine In dichloromethane at 20℃; for 6h;	98%

bis(3-aminopropyl)amine (56-18-8) + benzyl chloroformate (501-53-1) → [3-(3-benzyloxycarbonylaminopropylamino)propyl]carbamic acid benzyl ester (183249-68-5)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 10℃; Temperature; Reagent/catalyst; Solvent;	97.1%

bis(3-aminopropyl)amine (56-18-8) + ethyl trifluoroacetate, (383-63-1) → N1,N9-bis(trifluoroacetyl)dipropylenetriamine trifluoacetate

Conditions	Yield
In water; acetonitrile Heating;	97%
In water; acetonitrile for 4h; Reflux;	97%
	93%
With water In acetonitrile for 3h; Heating / reflux;

bis(3-aminopropyl)amine (56-18-8) + p-toluenesulfonyl chloride (98-59-9) → 1,5,9-Tritosyl-1,5,9-triazanonane (35980-64-4)

Conditions	Yield
With sodium hydroxide In diethyl ether; water Heating / reflux;	96.5%
With potassium carbonate In water at 60℃; for 3h;	95%
With sodium hydroxide In dichloromethane at 20℃; for 3h;	90%

bis(3-aminopropyl)amine (56-18-8) + pivalaldehyde (630-19-3) + 1,1'-carbonyldiimidazole (530-62-1) → bis[3-(t-butoxycarbonylamino)propyl]amine (82409-02-7)

Conditions	Yield
Stage #1: pivalaldehyde; 1,1'-carbonyldiimidazole With potassium hydroxide In toluene at 60℃; for 3h; Stage #2: bis(3-aminopropyl)amine In toluene at 60℃; for 3h; Further stages.;	96%

bis(3-aminopropyl)amine (56-18-8) + 1,7-di-(5-norbornen-2-yl)-4-heptanone (60469-45-6) → 1-[1,7-Di-(5-norbornen-2-yl)-4-heptyl]-1,5,9-Triazanonane Trihydrochloride

Conditions	Yield
With hydrogenchloride; sodium borohydrid In water; isopropyl alcohol; toluene	96%
With hydrogenchloride; sodium borohydrid In water; isopropyl alcohol; toluene	96%

bis(3-aminopropyl)amine (56-18-8) + molybdenum hexacarbonyl (13939-06-5, 199620-15-0) → fac-[(H2N(CH2)3NH(CH2)3NH2)Mo(CO)3] (161334-70-9)

Conditions	Yield
In dibutyl ether N2-atmosphere; slight excess metal carbonyl, refluxing for 2 h (returning sublimed hexacarbonyl into reaction vessel); cooling to room temp., collection of ppt., washing (hexane), drying (vac., 50°C);	96%

bis(3-aminopropyl)amine (56-18-8) + N,N-diethyl-3-iodobenzamide (15930-60-6) → 3,3'-[3,3'-azanediyl-bis(propane-3,1-diyl)bis(azanediyl)]bis(N,N-diethylbenzamide) (1351684-33-7)

Conditions	Yield
With copper(l) iodide; caesium carbonate; rac-Pro-OH In propiononitrile for 24h; Ullmann reaction; Inert atmosphere; Reflux; regioselective reaction;	96%

bis(3-aminopropyl)amine (56-18-8) + terephthalaldehyde, (623-27-8) → C28H38N6 (124481-60-3)

Conditions	Yield
In tetrahydrofuran at 0℃; for 5h;	95%
In tetrahydrofuran at -5℃; for 24h;	70%

bis(3-aminopropyl)amine (56-18-8) + 1.4-dibromobenzene (106-37-6) → N1-(3-aminopropyl)-N3-(4-bromophenyl)propane-1,3-diamine

Conditions	Yield
With sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane Substitution; Amination; Heating;	95%
With 1,3-bis(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In 1,4-dioxane for 30h; Heating;	95%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate In 1,4-dioxane for 20h; Heating;	64%

bis(3-aminopropyl)amine (56-18-8) + C21H30N2O5S2 (869193-31-7) → C36H67N5O4S4 (869193-32-8)

Conditions	Yield
In toluene at 20℃; for 1h;	95%

bis(3-aminopropyl)amine (56-18-8) + (di(3-aminopropyl)amine)trichloro cobalt(III) (15555-49-4, 131485-81-9, 75918-15-9) → mer-{Co(di(3-aminopropyl)amine)2}Cl3

Conditions	Yield
In isopropyl alcohol refluxing a mixt. of the Co-compd. and the amine for 0.5 h; pptn. after cooling, filtering off, washing with EtOH and acetone, air-drying;	95%

bis(3-aminopropyl)amine (56-18-8) + sodium azide + copper(II) perchlorate hexahydrate → [Cu(dipropylenetriamine)(μ-N3)]2(ClO4)2

Conditions	Yield
In water Cu(ClO4)2*6H2O was dissolved in water, ligand was added with stirring, soln. of NaN3 in water was added, stirred for 0.5 h; crystd. for 1 w; elem. anal.;	95%

bis(3-aminopropyl)amine (56-18-8) + Iron(III) nitrate nonahydrate + sodium tetraphenyl borate (143-66-8) + salicylaldehyde (90-02-8) + acetonitrile (75-05-8) → [((4-azaheptane-1,7-bis(salicylideneiminato))Fe)2(OH)][B(C6H5)4]*2(acetonitrile)*H2O

Conditions	Yield
With C5H5N In methanol salicylaldehyde and 3,3'-diaminodipropylamine mixed in MeOH, Fe salt in MeOH added, C5H5N added, stirred for 1 h, Na salt added; pptd. for hours, filtered, washed (Et2O), dried at room temp., recrystd.(MeCN); elem. anal.;	95%

bis(3-aminopropyl)amine (56-18-8) + C24H35N3O4 → C63H101N3O6

Conditions	Yield
In tetrahydrofuran at 23℃; for 2h;	95%

bis(3-aminopropyl)amine (56-18-8) + tert-butyl 1H-imidazole-1-carboxylate (49761-82-2) → bis[3-(t-butoxycarbonylamino)propyl]amine (82409-02-7)

Conditions	Yield
In toluene at 60℃; for 18h;	95%
In tetrahydrofuran at 20℃; Reflux;	80%
at 60℃; for 4h;	66%

Upstream product

• 111-94-4 3,3'-Iminodipropionitrile 
• 142-28-9 1,3-Dichloropropane 
• 35513-93-0 N¹-(cyanoethyl)-1,3-propanediamine 
• 503-29-7 azetidine 
• 109-76-2 Trimethylenediamine 
• 54262-75-8 N-γ-aminopropyltrimethyleneimine 
• 504-63-2 trimethyleneglycol 
• 7664-41-7 ammonia 
• 109-64-8 1,3-dibromo-propane 
• 167568-21-0 bis-(3-amino-propyl)-carbamic acid tert-butyl ester 
• 2664-61-1 3,3',3''-nitrilotripropanamide 
• 146724-95-0 dipropylenetriamine NONOate 
• 107-15-3 ethylenediamine 
• 14753-26-5 3-chloropropan-1-amine 

Downstream Products

• 52279-45-5 2,2′-((1E,1′E)-((azanediylbis(propane-3,1-diyl))bis-(azanylylidene))-bis(methanylylidene))-diphenol 
• 31962-42-2 bis-[3-(2,5-dimethyl-pyrrol-1-yl)-propyl]-amine 
• 90951-47-6 1,5,9-triformyl-1,5,9-triazanonane 
• 111355-64-7 [3-([Bis-(4-dimethylamino-phenoxy)-thiophosphoryl]-{3-[bis-(4-dimethylamino-phenoxy)-thiophosphorylamino]-propyl}-amino)-propyl]-thiophosphoramidic acid O,O'-bis-(4-dimethylamino-phenyl) ester 
• 13998-73-7 N,N'-(iminodipropane-1,3-diyl)distearamide 
• 111355-61-4 [3-([Bis-(3-dimethylamino-phenoxy)-thiophosphoryl]-{3-[bis-(3-dimethylamino-phenoxy)-thiophosphorylamino]-propyl}-amino)-propyl]-thiophosphoramidic acid O,O'-bis-(3-dimethylamino-phenyl) ester 
• 4605-14-5 N,N'-bis-(3-aminopropyl)-1,3-propanediamine 
• 128750-16-3 N-3-Phenylpropyl-N'-<3-(3-phenylpropylamino)-propyl>-propan-1,3-diamin-trihydrochlorid 
• 88412-04-8 bis-[3-(2-hydroxy-4-methoxy-benzylidenamino)-propyl]-amine 
• 82409-01-6 {3-[tert-Butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-propyl}-carbamic acid tert-butyl ester 
• 82409-04-9 tert-butyl N-{3-[(3-aminopropyl)amino]propyl}carbamate 

Relevant academic research and scientific papers

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Two copper(II) complexes, 1 and 2 with L1 and L2 [L1 = propane-1,3-diamine; L2 = N-isopropylpropane-1,3-diamine], respectively, were synthesized and characterized structurally. In acetonitrile solution of the complexes, the Cu(II) centre was found to reduce in presence of nitric oxide gas. The formation of [CuII-NO] intermediate prior to the reduction of Cu(II) center was evidenced by UV-Vis, solution FT-IR, X-band EPR studies. This reduction led to the ligand transformation through diazotization at primary amine site in complex 1; whereas, N-nitrosation at the secondary amine site of the ligand was observed in 2. The final organic products were isolated and characterized by spectroscopic studies.

Decomposition of amino diazeniumdiolates (NONOates): Molecular mechanisms

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The present invention relates to certain polyamine thiols which are useful as radioprotective agents.

A facile synthesis of the intermediates of the bicyclic organic bases: DBU and TBD

Intermediates of DBU and TBD, N-(3-aminoproply) - ε -caprolactam and bis- (3-aminopropyl)-amine were prepared by the hydrogenolysis of N-(2-cyanoethyl) - ε - caprolactam and di- (β-cyanoethyl)-amine respectively over Raney-Ni in the presence of NaBH4 under atmospheric pressure with mild condition and good yield.

Process for the dyeing of leather with anionic dyes and polyaminoamide resin as dyeing auxiliary

To improve the affinity of anionic dyestuffs in the dyeing of leather materials, polycondensation products consisting of at least one amine of the formula STR1 in which the radicals have the meanings mentioned in the description with one dicarboxylic acid and, if desired, ω-aminocarboxylic acid or its lactam are highly suitable.

KINETIC AND MECHANISM OF THE AMINATION OF AZETIDINE AND 1-(3-AMINOPROPYL)AZETIDINE

The kinetics and mechanism of decyclization reactions of azetidine and 1-(3-aminopropyl)azetidine with ammonia and 1,3-propanediamine were investigated.It was shown that for these reactions specific acid catalysis is realized.It was also shown that substitution on the nitrogen atom does not appreciably influence the reactivity of the four-mmembered heterocycle.