56-18-8 Usage
Chemical Properties
colourless to yellow liquid
Uses
Different sources of media describe the Uses of 56-18-8 differently. You can refer to the following data:
1. A structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.
2. Bis(3-aminopropyl)amine (BAPA) can be used:To synthesize chitosan based hydrogels having potential biomedical applications.For the functionalization of nanoparticles to yield terminal ?NH2 groups for further modifications. As an internal dispersing agent for the synthesis of water-dispersible polyurethanes.As a ligand in the preparation of [Cu(bapa)]2[Mo(CN)8]·7H2O photomagnetic coordination polymer.
Synthesis Reference(s)
The Journal of Organic Chemistry, 58, p. 3736, 1993 DOI: 10.1021/jo00066a028Journal of the American Chemical Society, 105, p. 5002, 1983 DOI: 10.1021/ja00353a025
General Description
A colorless liquid. Less dense than water. Flash point of 170°F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.
Air & Water Reactions
Water soluble.
Reactivity Profile
DIPROPYLENETRIAMINE neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. DIPROPYLENETRIAMINE can react with oxidizing materials .
Hazard
Toxic by ingestion and inhalation; irritant.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Safety Profile
Poison by skin contact. Moderately toxic by ingestion. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NO,. An explosive
Purification Methods
Dry the amine with Na and distil it under vacuum. [Beilstein 4 IV 1278.]
Check Digit Verification of cas no
The CAS Registry Mumber 56-18-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56-18:
(4*5)+(3*6)+(2*1)+(1*8)=48
48 % 10 = 8
So 56-18-8 is a valid CAS Registry Number.
56-18-8Relevant articles and documents
Nitric oxide reactivity of copper(II) complexes of bidentate amine ligands
Kalita, Aswini,Kumar, Vikash,Mondal, Biplab
, p. 55 - 60 (2015/03/30)
Two copper(II) complexes, 1 and 2 with L1 and L2 [L1 = propane-1,3-diamine; L2 = N-isopropylpropane-1,3-diamine], respectively, were synthesized and characterized structurally. In acetonitrile solution of the complexes, the Cu(II) centre was found to reduce in presence of nitric oxide gas. The formation of [CuII-NO] intermediate prior to the reduction of Cu(II) center was evidenced by UV-Vis, solution FT-IR, X-band EPR studies. This reduction led to the ligand transformation through diazotization at primary amine site in complex 1; whereas, N-nitrosation at the secondary amine site of the ligand was observed in 2. The final organic products were isolated and characterized by spectroscopic studies.
TRANSAMINATION OF NITROGEN-CONTAINING COMPOUNDS TO MAKE CYCLIC AND CYCLIC/ACYCLIC POLYAMINE MIXTURES
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Page/Page column 18-21, (2012/05/31)
A transamination process is described to prepare polyamine product mixtures from reactants comprising mixed nitrogen-containing compounds with binary carbon spacing between nitrogen-containing groups (a binary component). A second nitrogen-containing component with a second carbon atom spacing between nitrogen-containing groups may also be employed. The molar ratio between the binary and second components can be adjusted to customize the product composition for desired end uses.
METHOD FOR PRODUCING BIS-[(3-DIMETHYLAMINO)PROPYL]AMINE (DIPROPYLENE TRIAMINE, DPTA)
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Page/Page column 2; 3; 9, (2008/06/13)
The invention relates to a method for producing bis-[(3-dimethylamino)propyl]amine (dipropylene triamine, DPTA) by continuously reacting 1,3-propylene diamine (1,3-PDA) in the presence of a heterogeneous catalyst. The inventive method is characterized by