(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole

Base Information

Chemical Name:(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole
CAS No.:1152313-76-2
Molecular Formula:C26H28NOP
Molecular Weight:401.480381
Hs Code.:
Mol file:1152313-76-2.mol

Synonyms:(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole;(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole 97%

Suppliers and Price of (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole 97%
500mg
$ 183.00

Total 5 raw suppliers

Chemical Property of (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole

Chemical Property:

Melting Point:124-128°C
PSA：35.18000
LogP:4.46040

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25-36/37/38-53
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Uses Use of 5,5-(Dimethyl)-i-Pr-PHOX as a Practical Equivalent to t-Bu-PHOX in Asymmetric CatalysisDesign, Synthesis, and Applications of Potential Substitutes of t-Bu-Phosphinooxazoline in Pd-Catalyzed Asymmetric Transformations and Their Use for the Improvement of the Enantioselectivity in the Pd-Catalyzed Allylation Reaction of Fluorinated Allyl Enol Carbonates

Technology Process of (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole

There total 9 articles about (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1152313-75-1
(S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

: 829-85-6
diphenylphosphane

: 1152313-76-2
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole

Guidance literature:: diphenylphosphane; With potassium hydride; Diphenylphosphine oxide; In toluene; at 20 - 120 ℃; Inert atmosphere;

(S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole; In toluene; at 120 ℃; Inert atmosphere;
DOI:10.1021/ol9005618

Reference yield:

: 1152313-78-4
(S)-2-(2-bromophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole

: 829-85-6
diphenylphosphane

: 1152313-76-2
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In toluene; at 20 - 110 ℃; Inert atmosphere;
DOI:10.1021/ol9005618

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1152313-76-2
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 65 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere

5: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere

6: methanesulfonic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

7: potassium hydride / toluene / 20 - 120 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; methanesulfonic acid; water; potassium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; 3: Grignard reaction;
DOI:10.1021/jo2019653