(R)-4-PHENYLMETHOXY-MANDELONITRILE

Base Information

• Chemical Name: (R)-4-PHENYLMETHOXY-MANDELONITRILE
• CAS No.: 189683-89-4
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Mol file: 189683-89-4.mol

Synonyms:(R)-4-PHENYLMETHOXY-MANDELONITRILE

Chemical Property of (R)-4-PHENYLMETHOXY-MANDELONITRILE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(R)-4-PHENYLMETHOXY-MANDELONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-PHENYLMETHOXY-MANDELONITRILE

There total 12 articles about (R)-4-PHENYLMETHOXY-MANDELONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-benzyloxybenzaldehyde (4397-53-9) + sodium cyanide (143-33-9,25596-52-5) → α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4)

Guidance literature:

With ammonium chloride; In diethyl ether; at 5 ℃; for 24h;

DOI:10.1021/jm9800402

Reference yield: 90.0%

p-benzyloxybenzaldehyde (4397-53-9) + potassium cyanide (151-50-8) → α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4)

Guidance literature:

With ammonium chloride; In diethyl ether; water; at 20 ℃; for 48h;

Reference yield: 90.0%

p-benzyloxybenzaldehyde (4397-53-9) → α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4)

Guidance literature:

With potassium cyanide; ammonium chloride; In diethyl ether; water; at 20 ℃; for 48h;

upstream raw materials:

p-benzyloxybenzaldehyde

potassium cyanide

(4-benzyloxy-phenyl)-trimethylsilanyloxy-acetonitrile

sodium cyanide

Downstream raw materials:

6-Chloro-2,3,4,5-tetrahydro-8-hydroxy-1-(4-hydroxyphenyl)-7-methoxy-1H-3-benzazepine hydrochloride

6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Refernces

• 1、 Kim, Kicheol,Moeljadi, Adhitya Mangala Putra,Hirao, Hajime,Hong, Soon Hyeok. "Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex". supporting information. p. 3292 - 3298. Retrieved 2017/09/06.
• 2、 -. "MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN". Page/Page column 45-46. . Retrieved 2008/12/07.