6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Base Information

Chemical Name:6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride
CAS No.:110038-79-4
Molecular Formula:C₁₇H₁₈ClNO₃*ClH
Molecular Weight:356.249
Hs Code.:

Synonyms:

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Chemical Property of 6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

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Technology Process of 6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

There total 15 articles about 6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110039-01-5
α-<<<2-(2-Chloro-3-hydroxy-4-methoxyphenyl)ethyl>amino>methyl>-4-hydroxybenzenemethanol hydrochloride

: 110038-79-4
6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Guidance literature:: With hydrogenchloride; sulfuric acid; In trifluoroacetic acid; for 0.25h; Heating;
DOI:10.1002/jhet.5570230641

Reference yield: 21.0%

: 67287-53-0
6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 110038-79-4
6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Guidance literature:: With hydrogenchloride; at 99 - 101 ℃; for 13h;
DOI:10.1002/jhet.5570230641

Reference yield:

: 621-59-0
isovanillin

: 110038-79-4
6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: 71 percent / Cl₂ / CH₂Cl₂ / 1.) -20 to -25 deg C, 6 h, 2.) room temperature, overnight;

2: 83 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

3: 67 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

4: 92 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

5: 57 percent / dimethylsulfoxide / 3 h / Ambient temperature

6: 79 percent / aq. 25percent NaOH / ethanol / Heating; overnight

7: SOCl₂ / CH₂Cl₂ / 2.5 h / Heating

8: K₂CO₃ / H₂O; toluene; CH₂Cl₂ / 1 h

9: 82 percent / 1.) borane, 2.) methanol, 3.) HCl gas; / 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;

10: 77 percent / H₂ / 10percent palladium on carbon / ethanol; methanol

11: 54 percent / 1.) H₂SO₄, 2.) methanolic HCl; / trifluoroacetic acid / 0.25 h / Heating

With hydrogenchloride; methanol; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; borane; hydrogen; chlorine; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene; trifluoroacetic acid;
DOI:10.1002/jhet.5570230641