4-Benzylpiperidine hydrochloride

Base Information

• Chemical Name: 4-Benzylpiperidine hydrochloride
• CAS No.: 23239-75-0
• Molecular Formula: C12H17 N . Cl H
• Molecular Weight: 211.735
• Hs Code.: 2933399090
• UNII: ZV038SK23M
• DSSTox Substance ID: DTXSID20177809
• Wikidata: Q27295897
• Mol file: 23239-75-0.mol

Synonyms:4-BENZYLPIPERIDINE HYDROCHLORIDE;23239-75-0;4-benzylpiperidine;hydrochloride;4-(Phenylmethyl)piperidine hydrochloride;UNII-ZV038SK23M;ZV038SK23M;Piperidine, 4-(phenylmethyl)-, hydrochloride;Piperidine, 4-benzyl-, hydrochloride;4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE;Piperidine, 4-(phenylmethyl)-, hydrochloride (1:1);4-benzylpiperidine.HCl;SCHEMBL4935892;DTXSID20177809;AKOS015966717;AM80984;LS-115906;Piperidine, 4-benzyl-, hydrochloride (8CI);Q27295897;F9995-3595

Chemical Property of 4-Benzylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00397mmHg at 25°C
• Boiling Point: 279.6°Cat760mmHg
• Flash Point: 125.4°C
• PSA: 12.03000
• Density: g/cm³
• LogP: 3.35950
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 211.1127773
• Heavy Atom Count: 14
• Complexity: 132

Purity/Quality:

95%,98%, ^*data from raw suppliers

4-BENZYLPIPERIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CC2=CC=CC=C2.Cl

Technology Process of 4-Benzylpiperidine hydrochloride

There total 6 articles about 4-Benzylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Benzoylpyridine (14548-46-0) → 4-benzylpiperidin-1-ium chloride (23239-75-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; 1,2-dichloro-ethane; at 45 ℃; for 4.5h; Reagent/catalyst; Time; Pressure; Temperature; chemoselective reaction;

DOI:10.1016/j.tet.2013.12.017

Reference yield: 95.0%

3-bromo-α-phenyl-4-pyridinemethanol (234111-13-8) → 4-benzylpiperidin-1-ium chloride (23239-75-0)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 80 ℃; for 18h; under 45004.5 Torr; Autoclave;

DOI:10.1002/ejoc.201900450

Reference yield:

benzaldehyde (100-52-7) → 4-benzylpiperidin-1-ium chloride (23239-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.42 h / -85 °C

1.2: 0.25 h / -85 °C

2.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol; water / 18 h / 80 °C / 45004.5 Torr / Autoclave

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; hexane; water;

DOI:10.1002/ejoc.201900450

upstream raw materials:

4-Benzoylpyridine

3-bromo-α-phenyl-4-pyridinemethanol

benzaldehyde

3-Bromopyridine

Downstream raw materials:

N-{4-[2-(4-Benzyl-piperidin-1-ylmethyl)-acryloyl]-phenyl}-benzamide; hydrochloride

2-(4-Benzyl-piperidin-1-ylmethyl)-1-(4-nitro-phenyl)-propenone; hydrochloride

1-(4-Benzyl-piperidin-1-yl)-cyclohexanecarbonitrile

1-(4-Benzyl-piperidin-1-yl)-4-methyl-cyclohexanecarbonitrile