4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine

Base Information

Chemical Name:4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine
CAS No.:1421372-02-2
Molecular Formula:C₂₅H₂₇N₇O₃
Molecular Weight:473.534
Hs Code.:
Mol file:1421372-02-2.mol

Synonyms:4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine

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Chemical Property of 4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine

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Technology Process of 4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine

There total 7 articles about 4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methyl-1-piperazinyl)-5-nitrophenyl]-5-methyl-2-Pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 945016-62-6
3-(2-chloro-5-methylpyrimidin-4-yl)-1H-indole

: 1421372-03-3
2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitroaniline

: 1421372-02-2
4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-5-methylpyrimidin-2-amine

Guidance literature:: With toluene-4-sulfonic acid; at 120 ℃; for 24h;

Reference yield:

: 1421372-04-4
(2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)carbamic acid tert-butyl ester

: 1421372-02-2
4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-5-methylpyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: toluene-4-sulfonic acid / 24 h / 120 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1421372-05-5
2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrobenzoic acid

: 1421372-02-2
4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-5-methylpyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; diphenylphosphoranyl azide / 2 h / Reflux

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: toluene-4-sulfonic acid / 24 h / 120 °C

With diphenylphosphoranyl azide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;