1421372-04-4

Usage

Uses

Used in Pharmaceutical Industry:
(2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)carbamic acid tert-butyl ester is used as a starting material or intermediate for the synthesis of various pharmaceutical compounds. Its role in the development of new drugs with potential therapeutic applications makes it a valuable component in the pharmaceutical industry.
Used in Medicinal Chemistry Research:
As a carbamate derivative, (2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)carbamic acid tert-butyl ester is used as a reagent in organic synthesis, contributing to the advancement of medicinal chemistry research. Its potential applications in creating new drug candidates with therapeutic benefits are of significant interest to researchers in this field.
Used in Antimicrobial and Antitumor Applications:
(2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)carbamic acid tert-butyl ester has been reported to exhibit antimicrobial and antitumor activities in some studies. This makes it a potential candidate for use in the development of treatments targeting microbial infections and cancer, further expanding its relevance in the pharmaceutical sector.

Upstream product

• 1421372-05-5 2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrobenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 109-01-3 1-methyl-piperazine 
• 115919-39-6 2-methoxy-4,5-dinitrobenzoic acid 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 450-91-9 4-fluoro-2-methoxyaniline 
• 1075705-01-9 4-fluoro-2-methoxy-5-nitro-phenylamine 
• 1802924-13-5 (4-fluoro-2-methoxy-5-nitrophenyl)carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1421372-01-1 N'-[4-(1H-indol-3-yl)-5-methylpyrimidin-2-yl]-4-methoxy-6-(4-methylpiperazin-1-yl)benzene-1,3-diamine 
• 1421372-02-2 4-(1H-indol-3-yl)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-5-methylpyrimidin-2-amine 
• 1421372-03-3 2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitroaniline 
• 1421372-35-1 6-methoxy-4-(4-methylpiperazin-1-yl)-N₁-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 1421372-40-8 1-[5-amino-2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]guanidine 
• 1421372-41-9 1-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]guanidine 
• 1421373-40-1 C₂₈H₃₁N₇O₂ 
• 1421373-53-6 N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide 

Relevant academic research and scientific papers

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold

Based upon the modeling binding mode of marketed AZD9291 with T790M, a series of N-9-Diphenyl-9H-purin-2-amine derivatives were designed and synthesized with the purpose to overcome the drug resistance resulted from T790M/L858R double mutations. The most potent compound 23a showed excellent enzyme inhibitory activities and selectivity with nanomolar IC50 values for both the single T790M and double T790M/L858R mutant EGFRs, and was more than 8-fold selective for wild type EGFR. Compound 23a displayed strong antiproliferative activity against the H1975 non-small cell lung cancer (NSCLC) cells bearing T790M/L858R. And it was less potent against A549 (WT EGFR and k-Ras mutation) and HT-29 (non-special gene type) cells, showing a high safety index.

Azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof

The invention relates to azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof. Specifically, the invention discloses compounds represented by a formula (I), or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. The invention also provides preparation methods of the derivatives, and applications of the derivatives in EGFR inhibitors. The definitions of the groups in the formula are defined in the specifications.

2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER

The present invention relates to certain 2-(2,4,5-substituted-anilino) pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.