(6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine

Base Information

Chemical Name:(6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine
CAS No.:445263-72-9
Molecular Formula:C16H16BrN5O
Molecular Weight:374.24
Hs Code.:
Mol file:445263-72-9.mol

Synonyms:(6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine;GS-9973 intermediate;6-Bromo-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine;6-bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine

Suppliers and Price of (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine 97%
1g
$ 681.00

Total 2 raw suppliers

Chemical Property of (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine

Chemical Property:

PSA：54.69000
LogP:3.21000

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine

There total 3 articles about (6-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-morpholin-4-yl-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 445263-72-9
6-bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazine-8-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 85 ℃; for 8h;
DOI:10.1016/j.bioorg.2019.103547

Reference yield:

: 10389-51-2
1-morpholino-4-nitrobenzene

: 445263-72-9
6-bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazine-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; tetrahydrofuran / 0.08 h

1.2: 0.5 h

1.3: 3 h / 17 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 16 h / 100 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; isopropyl alcohol;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 445263-72-9
6-bromo-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazine-8-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 5 h / 80 °C

2: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 8 h / 75 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

With palladium 10% on activated carbon; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol;
DOI:10.1016/j.bioorg.2019.103547