2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

Base Information

• Chemical Name: 2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine
• CAS No.: 640725-73-1
• Molecular Formula: C11H16N6O4
• Molecular Weight: 296.28
• Mol file: 640725-73-1.mol

Synonyms:2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine;2,6-DiaMinopurine -9-beta-D-(2'-C-Methyl)riboside;2-Amino-2'-C-methyladenosine

Chemical Property of 2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

Chemical Property:

• PSA: 165.56000
• LogP: -0.84530

Purity/Quality:

97% ^*data from raw suppliers

(2R,3R,4R,5R)-2-(2,6-Diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine

There total 5 articles about 2,6-DiaMino-9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-diamino-9Hpurin-9-yl)-3-methyltetrahydrofuran-3,4-diyl Dibenzoate (1412427-05-4) → (2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-73-1)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 36h;

DOI:10.1021/jm501874e

Reference yield: 88.9%

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate (641571-44-0) → (2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-73-1)

Guidance literature:

With ammonia; In 1,4-dioxane; water; at 100 ℃; sealed tube;

Reference yield: 57.5%

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-74-2) → (2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-73-1)

Guidance literature:

With ammonium hydroxide; at 80 ℃;

DOI:10.1021/jm030424e

upstream raw materials:

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol

2-Amino-6-chloropurin

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-diamino-9Hpurin-9-yl)-3-methyltetrahydrofuran-3,4-diyl Dibenzoate