2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside

Base Information

• Chemical Name: 2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside
• CAS No.: 1412427-05-4
• Molecular Formula: C32H28N6O7
• Molecular Weight: 608.61
• Mol file: 1412427-05-4.mol

Synonyms:2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside;2-Amino-2'-C-methyladenosine 2',3',5'-tribenzoate

Chemical Property of 2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside

There total 1 articles about 2,6-DiaMinopurine -9-beta-D-(2',3',5'-tri-O-benzoyl-2'-C-Methyl) riboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2S/R,3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyltetrahydrofuran-2,3,4-triyltribenzoate + 2,6-diaminopurine (1904-98-9) → (2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-diamino-9Hpurin-9-yl)-3-methyltetrahydrofuran-3,4-diyl Dibenzoate (1412427-05-4)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at -78 - 65 ℃;

Reference yield: 93.0%

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-diamino-9Hpurin-9-yl)-3-methyltetrahydrofuran-3,4-diyl Dibenzoate (1412427-05-4) → (2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-73-1)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 36h;

DOI:10.1021/jm501874e

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + (2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-diamino-9Hpurin-9-yl)-3-methyltetrahydrofuran-3,4-diyl Dibenzoate (1412427-05-4) → (2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-bis(bis(tertbutoxycarbonyl)amino)-9H-purin-9-yl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate (1412427-06-5)

Guidance literature:

dmap; In tetrahydrofuran; at 20 ℃; for 30h;

upstream raw materials:

2,6-diaminopurine

Downstream raw materials:

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,6-bis(bis(tertbutoxycarbonyl)amino)-9H-purin-9-yl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate

(2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol