2-HYDROXY-4-BROMO-6-NITROTOLUENE

Base Information

• Chemical Name: 2-HYDROXY-4-BROMO-6-NITROTOLUENE
• CAS No.: 864550-41-4
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Mol file: 864550-41-4.mol

Synonyms:2-HYDROXY-4-BROMO-6-NITROTOLUENE

Chemical Property of 2-HYDROXY-4-BROMO-6-NITROTOLUENE

Chemical Property:

• Melting Point: 88 °C
• Boiling Point: 312.1±42.0 °C(Predicted)
• PKA: 8.16±0.25(Predicted)
• PSA: 66.05000
• Density: 1.755±0.06 g/cm3(Predicted)
• LogP: 2.89450

Purity/Quality:

95% ^*data from raw suppliers

5-Bromo-2-methyl-3-nitrophenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-HYDROXY-4-BROMO-6-NITROTOLUENE

There total 3 articles about 2-HYDROXY-4-BROMO-6-NITROTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-bromo-2-methyl-3-nitroaniline (864550-40-3) → 5-bromo-2-methyl-3-nitrophenol (864550-41-4)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 150 ℃;

Reference yield:

2,6-dinitrotoluene (606-20-2) → 5-bromo-2-methyl-3-nitrophenol (864550-41-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 1 h / 20 °C

2.1: pyridine; diammonium sulfide / ethanol; water / 3 h / Reflux

3.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C

3.2: 130 °C

With pyridine; diammonium sulfide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; sodium nitrite; In ethanol; water;

DOI:10.1021/ol503348n

Reference yield:

5-bromo-2-methyl-1,3-dinitrobenzene (95192-64-6) → 5-bromo-2-methyl-3-nitrophenol (864550-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; diammonium sulfide / ethanol; water / 3 h / Reflux

2.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C

2.2: 130 °C

With pyridine; diammonium sulfide; sulfuric acid; sodium nitrite; In ethanol; water;

DOI:10.1021/ol503348n

upstream raw materials:

5-bromo-2-methyl-3-nitroaniline

2,6-dinitrotoluene

5-bromo-2-methyl-1,3-dinitrobenzene

Downstream raw materials:

6-bromo-4-methoxyindole

5-bromo-1-methoxy-2-methyl-3-nitrobenzene

1-benzyloxy-5-bromo-2-methyl-3-nitro-benzene

Refernces

• 1、 -. "Pyranouidole Derivatives and the Use Thereof for the Treatment of Hepatitis C Virus Infection or Disease". Page/Page column 18-19. . Retrieved 2010/11/28.