6-BROMO-4-METHOXYINDOLE

Base Information

• Chemical Name: 6-BROMO-4-METHOXYINDOLE
• CAS No.: 393553-57-6
• Molecular Formula: C9H8 Br N O
• Molecular Weight: 226.073
• Hs Code.: 2933990090
• Mol file: 393553-57-6.mol

Synonyms:6-Bromo-4-methoxyindole

Chemical Property of 6-BROMO-4-METHOXYINDOLE

Chemical Property:

• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.667
• Boiling Point: 346.8°Cat760mmHg
• PKA: 16.29±0.30(Predicted)
• Flash Point: 163.5°C
• PSA: 25.02000
• Density: 1.591g/cm³
• LogP: 2.93900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-4-methoxy-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-METHOXYINDOLE

There total 13 articles about 6-BROMO-4-METHOXYINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 6-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole → 6-bromo-4-methoxyindole (393553-57-6)

Guidance literature:

With dmap; copper(II) acetate monohydrate; at 20 ℃; for 5h; Molecular sieve;

DOI:10.1016/j.tet.2017.10.067

Reference yield: 68.0%

C10H8BrNO3 → 6-bromo-4-methoxyindole (393553-57-6)

Guidance literature:

With 2C₁₀H₇BrNO₃^(1-)*Cu⁽²⁺⁾; In quinoline; at 215 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01702

Reference yield: 64.0%

1-(6-Bromo-4-methoxy-indol-1-yl)-2,2,2-trifluoro-ethanone + 1-(4-Bromo-6-methoxy-indol-1-yl)-2,2,2-trifluoro-ethanone → 6-bromo-4-methoxyindole (393553-57-6) + 4-bromo-6-methoxy-1H-indole (393553-55-4)

Guidance literature:

With methanol; potassium hydroxide; at 20 ℃; for 0.25h;

upstream raw materials:

2,6-dinitrotoluene

5-bromo-2-methyl-1,3-dinitrobenzene

5-bromo-2-methyl-3-nitroaniline

5-bromo-2-methyl-3-nitrophenol

Downstream raw materials:

6-bromo-4-methoxy-1H-indole-3-carbaldehyde

tryptamine

6-ethyl-1-(3-fluoro-4-hydroxyphenyl)-1H-indol-4-ol

6-ethyl-1-[3-fluoro-4-(methyloxy)phenyl]-4-(methyloxy)-1H-indole

Refernces

• 1、 Pandey, Sunil Kumar,Guttormsen, Yngve,Haug, Bengt Erik,Hedberg, Christian,Bayer, Annette. "A Concise Total Synthesis of Breitfussin A and B". . p. 122 - 125. Retrieved 2015/07/28.
• 2、 -. "3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof". Page/Page column 80. . Retrieved 2008/06/13.