rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide

Base Information

• Chemical Name: rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide
• CAS No.: 701977-00-6
• Molecular Weight: 0
• Mol file: 701977-00-6.mol

Synonyms:rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide

Chemical Property of rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide

There total 49 articles about rel- N-[(1R,2R)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-[(1Z)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylprop-1-en-1-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (876365-70-7) → taranabant (701977-09-5,701977-00-6)

Guidance literature:

With hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate; (R,S)-(di-t-butylphosphino)ferrocenyl-ethyldi-o-tolyl-phosphine; In 1,2-dichloro-ethane; at 80 ℃; for 18h; under 25858.1 Torr;

Reference yield: 94.0%

2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoic acid (605680-62-4) + 3-[(1S,2S)-2-amino-1-(4-chlorobenzyl)propyl]benzonitrile hydrochloride → taranabant (701977-09-5,701977-00-6)

Guidance literature:

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; In acetonitrile; at 50 ℃; for 4h; Inert atmosphere; Large scale;

DOI:10.1021/op700026n

Reference yield: 90.0%

3-{(1S,2S)-1-(4-chlorobenzyl)-2-[(2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoyl)amino]propyl}benzamide (876365-72-9) → taranabant (701977-09-5,701977-00-6)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; In Isopropyl acetate; N,N-dimethyl-formamide; at 25 ℃; for 1.5h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/op800270e

upstream raw materials:

2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoic acid

N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]amine hydrochloride

3-(3-bromophenyl)-4-(4-chlorophenyl)butan-2-one

ethyl 2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoate