1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester
• CAS No.: 374796-29-9
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Hs Code.: 2934999090
• Mol file: 374796-29-9.mol

Synonyms:1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester;4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester

Chemical Property of 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester

Chemical Property:

• Boiling Point: 406.7±45.0 °C(Predicted)
• PKA: 14.84±0.20(Predicted)
• PSA: 59.00000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 1.86530

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-hydroxy-1-oxa-9-azaspiro-[5.5]undecane-9-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester

There total 13 articles about 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

di-tert-butyl dicarbonate (24424-99-5) + 9-benzyl-1-oxa-9-azaspiro[5.5]undecan-4-ol (1785761-76-3) → tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374796-29-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; at 20 ℃; for 48h;

Reference yield: 24.0%

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate (374795-40-1) → tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374795-42-3) + tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374796-29-9)

Guidance literature:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate; With borane; In tetrahydrofuran; at 20 ℃; for 6.5h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

Reference yield: 19.0%

di-tert-butyl dicarbonate (24424-99-5) + C9H17NO2 → tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374796-29-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

upstream raw materials:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate

1-phenylmethyl-4-piperidone

9-benzyl-1-oxa-9-azaspiro[5.5]undecan-4-ol

methanesulfonic acid 9-benzyl-1-oxa-9-azaspiro[5.5]undec-4-yl ester