374795-40-1

Basic information

• Product Name: 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester
• Synonyms: 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester;1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester-4;Tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate
• CAS NO: 374795-40-1
• Molecular Formula: C14H23NO3
• Molecular Weight: 253.33732
• Mol File: 374795-40-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester(374795-40-1)
• EPA Substance Registry System: 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester(374795-40-1)

Safety Data

• Hazardous Substances Data: 374795-40-1(Hazardous Substances Data)

Usage

General Description

1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester is a chemical compound with the molecular formula C14H23NO3. It is commonly used as an ester in numerous industrial and research applications. 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester is known for its spirocyclic structure, which contains an oxygen atom and a nitrogen atom in a fused ring system. 1-Oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylic acid, 1,1-diMethylethyl ester has potential applications in pharmaceuticals, agrochemicals, and other fields based on its unique chemical properties. However, it is important to handle this compound with caution, as it may pose health and safety risks if not handled properly.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 374795-39-8 tert-butyl 4-allyl-4-(allyloxy)piperidine-1-carboxylate 
• 203662-51-5 1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine 

Downstream Products

• 374795-42-3 tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 374796-29-9 tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 1346229-46-6 tert-butyl 3-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 1346229-51-3 tert-butyl 4-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 

Relevant articles and documents

Nitroimidazole compound as well as preparation method and application thereof

The invention discloses a novel nitroimidazole compound as well as a preparation method and application thereof. The nitroimidazole compound has a general formula (I) shown in the specification.

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The GlaxoSmithKline (GSK) library yielded many high-quality hits, and the associated data were placed in the public domain to stimulate engagement by the wider community. One such series, the spiro compounds, are described here. The compounds were explored by a combination of traditional in-house research and open source methods. The series benefits from a particularly simple structure and a short associated synthetic chemistry route. Many members of the series displayed striking potency and low toxicity, and highly promising in vivo activity in a mouse model was confirmed with one of the analogues. Ultimately the series was discontinued due to concerns over safety, but the associated data remain public domain, empowering others to resume the series if the perceived deficiencies can be overcome.

Cyclohexane derivatives and their use as therapeutic agents

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.