Methyl 5-aMino-6-Methoxynicotinate

Base Information

• Chemical Name: Methyl 5-aMino-6-Methoxynicotinate
• CAS No.: 59237-50-2
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• Hs Code.: 2933399090
• Mol file: 59237-50-2.mol

Synonyms:Methyl 5-aMino-6-Methoxynicotinate;5-AMino-6-Methoxy-nicotinic acid Methyl ester

Chemical Property of Methyl 5-aMino-6-Methoxynicotinate

Chemical Property:

• Boiling Point: 334.8±37.0 °C(Predicted)
• PKA: 2.30±0.20(Predicted)
• PSA: 74.44000
• Density: 1.240±0.06 g/cm3(Predicted)
• LogP: 1.04020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-amino-6-methoxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-aMino-6-Methoxynicotinate

There total 2 articles about Methyl 5-aMino-6-Methoxynicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-5-nitro-nicotinic acid methyl ester (59237-49-9) → methyl 5-amino-6-(methylthio)nicotinate (166742-23-0) + methyl 5-amino-6-methoxy-nicotinate (59237-50-2)

Guidance literature:

palladium on carbon; In methyl 6-(methylthio)-5-nitronicotinate; ethyl acetate;

Reference yield:

→ methyl 5-amino-6-methoxy-nicotinate (59237-50-2)

Guidance literature:

Methyl-6-methoxy-5-nitronicotinat, H2, (Pd/C);

Reference yield:

sodium tetrafluoroborate (13755-29-8) + methyl 5-amino-6-methoxy-nicotinate (59237-50-2) → methyl 5-(hydroxy)-6-(methylthio)nicotinate (166742-24-1) + methyl 5-hydroxy-6-methoxypyridine-3-carboxylate (166742-16-1)

Guidance literature:

With concentrated hydrochloric acid; potassium carbonate; trifluoroacetic acid; sodium nitrite; In methyl 5-amino-6-(methylthio)nicotinate; water;

upstream raw materials:

6-methoxy-5-nitro-nicotinic acid methyl ester

Downstream raw materials:

methyl 5-(hydroxy)-6-(methylthio)nicotinate

methyl 5-hydroxy-6-methoxypyridine-3-carboxylate