Methyl 5-hydroxy-6-Methoxynicotinate

Base Information

• Chemical Name: Methyl 5-hydroxy-6-Methoxynicotinate
• CAS No.: 166742-16-1
• Molecular Formula: C8H9NO4
• Molecular Weight: 183.164
• Mol file: 166742-16-1.mol

Synonyms:Methyl 5-hydroxy-6-Methoxynicotinate

Chemical Property of Methyl 5-hydroxy-6-Methoxynicotinate

Chemical Property:

• Boiling Point: 392.6±37.0 °C(Predicted)
• PKA: 8.23±0.10(Predicted)
• PSA: 68.65000
• Density: 1.280±0.06 g/cm3(Predicted)
• LogP: 0.58240
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl5-hydroxy-6-methoxynicotinate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-hydroxy-6-Methoxynicotinate

There total 1 articles about Methyl 5-hydroxy-6-Methoxynicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium tetrafluoroborate (13755-29-8) + methyl 5-amino-6-methoxy-nicotinate (59237-50-2) → methyl 5-(hydroxy)-6-(methylthio)nicotinate (166742-24-1) + methyl 5-hydroxy-6-methoxypyridine-3-carboxylate (166742-16-1)

Guidance literature:

With concentrated hydrochloric acid; potassium carbonate; trifluoroacetic acid; sodium nitrite; In methyl 5-amino-6-(methylthio)nicotinate; water;

Reference yield: 82.5%

methyl 5-hydroxy-6-methoxypyridine-3-carboxylate (166742-16-1) + benzyl bromide (100-39-0) → methyl 5-benzyloxy-6-methoxypyridine-3-carboxylate

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

Reference yield:

methyl 5-hydroxy-6-methoxypyridine-3-carboxylate (166742-16-1) → 5-benzyloxy-6-methoxypyridine-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 25 °C

With lithium hydroxide monohydrate; water; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

sodium tetrafluoroborate

methyl 5-amino-6-methoxy-nicotinate

Refernces