1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-
CAS No.:221040-36-4
Molecular Formula:C17H28N2O6S
Molecular Weight:388.47902
Hs Code.:
Mol file:221040-36-4.mol

Synonyms:1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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1,2-Pyrrolidinedicarboxylicacid,2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]methyl]-,1-(1,1-dimethylethyl)2-methylester,(2R)-
100mg
$ 3300.00

Total 5 raw suppliers

Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-

Chemical Property:

Melting Point:94 - 97 °C
PSA：130.47000
LogP:2.09170

Purity/Quality:

≥95% ^*data from raw suppliers

1,2-Pyrrolidinedicarboxylicacid,2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]methyl]-,1-(1,1-dimethylethyl)2-methylester,(2R)- ^*data from reagent suppliers

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Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)-

There total 8 articles about 1,2-Pyrrolidinedicarboxylic acid, 2-[[(4R)-4-carboxytetrahydro-2H-1,3-thiazin-2-yl]Methyl]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 144085-24-5
(2R)-2-(2-oxoethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl 2-methyl ester

: D-homocysteine hydrochloride

: 221040-36-4
(2RS,4R)-2-<<2'-(R)-N-(tert-butoxycarbonyl)-2'-(methoxycarbonyl)pyrrolidinyl>methyl>thiazinane-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; Ambient temperature;
DOI:10.1021/jm980525q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 221040-36-4
(2RS,4R)-2-<<2'-(R)-N-(tert-butoxycarbonyl)-2'-(methoxycarbonyl)pyrrolidinyl>methyl>thiazinane-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Me₄NOH*5H₂O / acetonitrile / 48 h / Ambient temperature

2: diethyl ether

3: 1.) OsO₄, H₂O, 2.) aq. NaIO₄ / 1.) THF, RT, 5 min, 2.) THF, RT, overnight

4: 75 percent / aq. NaOH / aq. ethanol / Ambient temperature

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetramethyl ammoniumhydroxide; water; In diethyl ether; ethanol; acetonitrile;
DOI:10.1021/jm980525q

Reference yield:

: 81286-83-1
(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 221040-36-4
(2RS,4R)-2-<<2'-(R)-N-(tert-butoxycarbonyl)-2'-(methoxycarbonyl)pyrrolidinyl>methyl>thiazinane-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O, SiO₂ / methanol / 48 h / Ambient temperature

2: Me₄NOH*5H₂O / acetonitrile / 48 h / Ambient temperature

3: diethyl ether

4: 1.) OsO₄, H₂O, 2.) aq. NaIO₄ / 1.) THF, RT, 5 min, 2.) THF, RT, overnight

5: 75 percent / aq. NaOH / aq. ethanol / Ambient temperature

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetramethyl ammoniumhydroxide; water; silica gel; In methanol; diethyl ether; ethanol; acetonitrile;
DOI:10.1021/jm980525q