(R)-4-Phenylpyrrolidin-2-one

Base Information

• Chemical Name: (R)-4-Phenylpyrrolidin-2-one
• CAS No.: 71657-88-0
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol file: 71657-88-0.mol

Synonyms:(R)-4-Phenylpyrrolidin-2-one

Chemical Property of (R)-4-Phenylpyrrolidin-2-one

Chemical Property:

• Melting Point: 101-104 °C
• Boiling Point: 362.3±31.0 °C(Predicted)
• PKA: 16.13±0.40(Predicted)
• PSA: 29.10000
• Density: 1.108±0.06 g/cm3(Predicted)
• LogP: 1.61890

Purity/Quality:

97% ^*data from raw suppliers

(R)-4-Phenylpyrrolidin-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-Phenylpyrrolidin-2-one

There total 76 articles about (R)-4-Phenylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-1-((S)-2-(6-methoxynaphthalen-2-yl)propanoyl)-4-phenylpyrrolidin-2-one → (4R)-4-phenyl-2-pyrrolidone (71657-88-0)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.3390/molecules201219830

Reference yield: 99.0%

(R)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-4-phenyl-pyrrolidin-2-one (145549-06-0) → (4R)-4-phenyl-2-pyrrolidone (71657-88-0)

Guidance literature:

With ammonia; In tetrahydrofuran; ethanol; for 0.166667h;

DOI:10.1021/jo00053a012

Reference yield: 98.0%

4-phenyl-1,5-dihydro-2H-pyrrol-2-one (92119-61-4) → (4R)-4-phenyl-2-pyrrolidone (71657-88-0)

Guidance literature:

With bis(norbornadiene)rhodium(l)tetrafluoroborate; zhaophos; hydrogen; In dichloromethane; at 35 ℃; for 48h; under 45603.1 Torr; enantioselective reaction;

DOI:10.1021/acscatal.8b00827

upstream raw materials:

(αR,4R)-1-(1'-phenylethyl)-4-phenylpyrrolidin-2-one

(3R,4R)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide

(R)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-4-phenyl-pyrrolidin-2-one

(R)-1-(4-methoxyphenyl)-4-phenylpyrrolidin-2-one

Downstream raw materials:

(-)-(R)-3-Phenylpyrrolidine

2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide

(R)-4-amino-3-phenylbutanoioc acid hydrochloride

(R)-Phenibut

Refernces

• 1、 Sietmann, Jan,Ong, Mike,Mück-Lichtenfeld, Christian,Daniliuc, Constantin G.,Wiest, Johannes M.. "Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ-Lactams". supporting information. p. 9719 - 9723. Retrieved 2021/03/16.
• 2、 -. "COMPOUND, MANUFACTURING METHOD OF COMPOUND THROUGH ASYMMETRIC MICHAEL ADDITION USING THE COMPOUND AND MANUFACTURING METHOD OF PHENIBUT USING THE COMPOUND". Paragraph 0132-0135. . Retrieved 2018/05/16.