Methyl 2-vinylnicotinate

Base Information

• Chemical Name: Methyl 2-vinylnicotinate
• CAS No.: 103441-72-1
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176
• Mol file: 103441-72-1.mol

Synonyms:Methyl 2-vinylnicotinate;4-(1,2,3,6-tetrahydropyridin-4-yl)benzoic acid

Chemical Property of Methyl 2-vinylnicotinate

Chemical Property:

• PSA: 39.19000
• LogP: 1.51120

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-vinylnicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-vinylnicotinate

There total 7 articles about Methyl 2-vinylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 2-ethynylnicotinate (379670-43-6) → 2-ethenyl-3-pyridinecarboxylic acid methyl ester (103441-72-1)

Guidance literature:

With hydrogen; palladium; In ethyl acetate; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2012.07.001

Reference yield: 70.0%

methyl 2-chloropyridine-3-carboxylate (40134-18-7) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-ethenyl-3-pyridinecarboxylic acid methyl ester (103441-72-1)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 40 - 55 ℃; for 68h;

DOI:10.1002/jhet.5570430525

Reference yield:

methyl 2-chloropyridine-3-carboxylate (40134-18-7) + pinacol vinylboronate (75927-49-0) → 2-ethenyl-3-pyridinecarboxylic acid methyl ester (103441-72-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

methyl 2-chloropyridine-3-carboxylate

tri-n-butyl(vinyl)tin

2-chloronicotinic acid

methyl 2-((trimethylsilyl)ethynyl)nicotinate

Downstream raw materials:

7,8-Dihydro-1,6-Naphthyridine-5(6H)-one

7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one