40134-18-7

Basic information

• Product Name: METHYL 2-CHLORONICOTINATE
• Synonyms: METHYL 2-CHLORO-3-PYRIDINECARBOXYLATE;METHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE;METHYL 2-CHLORONICOTINATE;2-CHLORONICOTINIC ACID METHYL ESTER;2-CHLORO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;Methyl 2-chloronicotinate 98%;2-Chloro-3-pyridinecarboxylic acid methyl ester, 2-Chloro-nicotinic acid methyl ester;2-Chloropyridine-3-carboxylic acid methyl ester
• CAS NO: 40134-18-7
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 254-805-9
• Product Categories: blocks;Carboxes;Pyridines;Pyridine;pharmacetical;pyridine series
• Mol File: 40134-18-7.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 150 °C/1 mmHg
• Flash Point: 110 °C
• Appearance: Colorless/Liquid
• Density: 1.314 g/mL at 25 °C
• Vapor Pressure: 0.0429mmHg at 25°C
• Refractive Index: n 20/D 1.537
• Storage Temp.: Keep Cold
• PKA: -1.39±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-CHLORONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORONICOTINATE(40134-18-7)
• EPA Substance Registry System: METHYL 2-CHLORONICOTINATE(40134-18-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 40134-18-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloronicotinate is a chemical compound that belongs to the class of nicotinate derivatives. It is a derivative of nicotinic acid, also known as vitamin B3. METHYL 2-CHLORONICOTINATE is widely used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. Methyl 2-chloronicotinate is known for its mild, pleasant odor and it is commonly used as a flavoring agent in the food industry. It is also utilized as an intermediate in the production of agrochemicals, dyes, and other organic compounds. This chemical is considered to have low toxicity and is generally safe for use with proper handling and precautions.

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 2942-59-8 2-chloronicotinic acid 
• 7440-44-0 pyrographite 
• 67-56-1 methanol 
• 121495-79-2 2-chloropyridine-3-carbonyl chloride hydrochloride 
• 63270-91-7 β-dibutylaminoacroleine 
• 105-34-0 methyl 2-cyanoacetate 
• 927-63-9 3-dimethylaminoacrolein 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 36851-80-6 nitrosomethylurea 
• 74-88-4 methyl iodide 
• 56055-55-1 2-chloropyridin-3-carboxylic acid HCl salt 
• 56880-79-6 3-Ethyl-1-methyl-2-pyridon 
• 96440-05-0 2-chloro-3-ethylpyridine 

Downstream Products

• 208983-73-7 2-styrylnicotinic acid methyl ester 
• 103441-72-1 2-ethenyl-3-pyridinecarboxylic acid methyl ester 
• 935265-49-9 methyl 2-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)nicotinate 
• 188622-56-2 2-(2,5-Difluoro-benzyl)-nicotinic acid 
• 188622-58-4 2-(5-Chloro-2-fluoro-benzyl)-nicotinic acid 
• 188622-57-3 2-(2-Chloro-5-fluoro-benzyl)-nicotinic acid 
• 247117-47-1 Methyl 2-(4-Benzylpiperazin-1-yl)nicotinate 
• 157362-04-4 Methyl 2-allylaminopyridine-3-carboxylate 
• 36701-90-3 methyl-2-(3'-α,α,α,-trifluoromethyl-phenoxy)nicotinate 
• 256397-51-0 2-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester 
• 929541-51-5 2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester 
• 1301225-27-3 C₁₄H₉Cl₂NO₂ 
• 1301225-31-9 2-(4-chlorophenyl)-4H-pyrano[2,3-b]pyridin-4-one 
• 15441-52-8 2-phenyl-4H-pyrano[2,3-b]pyridin-4-one 

Relevant articles and documents

Preparation method of 2-chloro-N, N-dimethyl nicotinamide

The invention belongs to the technical field of pesticides, and particularly relates to a preparation method of 2-chloro-N, N-dimethyl nicotinamide. The preparation method of the 2-chloro-N, N-dimethyl nicotinamide comprises the following steps of taking 2-chloronicotinic acid as a raw material, and carrying out esterification reaction with methanol to obtain 2-chloronicotinic acid methyl ester, and carrying out aminolysis reaction with dimethylamine in the presence of a catalyst N, N-dimethyl nicotinamide to obtain the 2-chloro-N, N-dimethyl nicotinamide. The preparation method disclosed by the invention is mild and controllable in reaction, simple in process equipment, low in dimethylamine consumption, low in production cost and good in product quality, and the amount of wastewater is greatly reduced and is easy to treat.

A ultrasonic process for synthesizing 2 - halogenated nicotinate and intermediates thereof

The invention discloses a method for synthesizing 2-halogenated ester nicotinate and a 2-halogenated ester nicotinate intermediate according to an ultrasonic method. The method comprises the following steps: adding substituent amino acrolein, a catalyst and cyanacetic ester into a reactor for a reaction under ultrasonic radiation; tracing the reaction till substituent amino acrolein is disappeared, thereby obtaining a reaction solution I containing the 2-halogenated ester nicotinate intermediate; then, adding halogen hydride into the reaction solution I for another reaction to obtain a reaction solution II; tracing and monitoring the reaction till completion; adding a lye into the reaction solution II to adjust the pH value of the reaction solution II to be 5-6; carrying out standing stratification to obtain a water layer and an organic layer; conducting extraction on the water layer by utilizing an organic solvent, and then combining the extraction solution with the organic layer; carrying out refining to obtain 2-halogenated ester nicotinate. Through the adoption of the method, an organic synthesis reaction can be effectively facilitated, the reaction speed and yield can be improved, and the environmental protection can be promoted; the reaction time is short and the operation is simple, that is, the organic synthesis reaction can be finished within 2 hours in general; the product yield and quality are high; specifically, the product yield can reach 90% or higher, and exceed that achieved according to the conventional solvent heating reflux method.

Towards new sila- Or germa-derivatives of motesanib

– Developing new access to original silylated heterocycles is an emerging challenge in medicinal chemistry. In this paper, we describe a synthesis of silylated and germylated Motesanib analogues relying on a peptide coupling between a nicotinic acid derivative and silylated or germylated heterocycles, prepared according to our previous reports.