2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene

Base Information

• Chemical Name: 2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene
• CAS No.: 1312603-37-4
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.22522
• Mol file: 1312603-37-4.mol

Synonyms:2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene

Chemical Property of 2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene

Chemical Property:

• Boiling Point: 341.9±32.0 °C(Predicted)
• PSA: 64.28000
• Density: 1.159±0.06 g/cm3(Predicted)
• LogP: 2.82920

Purity/Quality:

97% ^*data from raw suppliers

2-((Allyloxy)methyl)-1-methoxy-4-nitrobenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene

There total 2 articles about 2-(allyloxyMethyl)-1-Methoxy-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-methoxy-5-nitrophenylmethanol (5804-49-9) + allyl bromide (106-95-6) → 2-allyloxymethyl-1-methoxy-4-nitrobenzene (1312603-37-4)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm200326p

Reference yield:

2-methoxy-5-nitrobenzaldehyde (25016-02-8) → 2-allyloxymethyl-1-methoxy-4-nitrobenzene (1312603-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 12 h / 20 °C

With sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm200326p

Reference yield: 88.0%

2-allyloxymethyl-1-methoxy-4-nitrobenzene (1312603-37-4) → 3-allyloxymethyl-4-methoxyphenylamine (1312603-44-3)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 50 - 80 ℃; for 4h;

DOI:10.1021/jm200326p

upstream raw materials:

2-methoxy-5-nitrobenzaldehyde

2-methoxy-5-nitrophenylmethanol

allyl bromide

Downstream raw materials:

3-allyloxymethyl-4-methoxyphenylamine

(3-allyloxymethyl-4-methoxyphenyl)-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-yl]amine

(3-allyloxymethyl-4-methoxyphenyl)-[4-(3-allyloxyphenyl)pyrimidin-2-yl]amine

(3-allyloxymethyl-4-methoxyphenyl)-[4-(3-allyloxymethylphenyl)pyrimidin-2-yl]amine