6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside

Base Information

• Chemical Name: 6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside
• CAS No.: 351009-26-2
• Molecular Formula: C₁₆H₁₆F₂O₈
• Molecular Weight: 374.295
• Hs Code.: 2938900000
• Mol file: 351009-26-2.mol

Synonyms:6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside;6,8-Difluoro-4-methylumbelliferyl beta-D-glucopyranoside min. 98%;6,8-Difluoro-7-(beta-D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one

Chemical Property of 6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside

Chemical Property:

• PSA: 129.59000
• LogP: -0.44170

Purity/Quality:

98% ^*data from raw suppliers

6,8-Difluoro-4-methylumbelliferyl b-D-glucopyranoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside

There total 8 articles about 6,8-Difluoro-4-methylumbelliferyl-b-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6',8'-difluoro-4’-methylumbelliferyl 2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside → 6',8'-difluoro-4’-methylumbelliferyl α-D-glucopyranoside (215868-26-1,351009-26-2)

Guidance literature:

With methanol; sodium methylate; for 1h;

Reference yield:

1,2,3,4-tetrafluorobenzene (551-62-2) → 6',8'-difluoro-4’-methylumbelliferyl α-D-glucopyranoside (215868-26-1,351009-26-2)

Guidance literature:

Multi-step reaction with 7 steps

1: methanol / 20 °C / Inert atmosphere; Cooling with ice

2: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 2327.23 Torr

3: hydrogenchloride; sodium nitrite / water / 0.42 h / -5 - 4 °C

4: boron tribromide / dichloromethane

5: methanesulfonic acid / Cooling with ice

6: boron trifluoride diethyl etherate; dmap / 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

7: sodium methylate; methanol / 1 h

With hydrogenchloride; methanol; dmap; methanesulfonic acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium methylate; boron tribromide; sodium nitrite; In methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

1,3-difluoro-2,4-dimethoxy-5-nitrobenzene (195136-63-1) → 6',8'-difluoro-4’-methylumbelliferyl α-D-glucopyranoside (215868-26-1,351009-26-2)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 2327.23 Torr

2: hydrogenchloride; sodium nitrite / water / 0.42 h / -5 - 4 °C

3: boron tribromide / dichloromethane

4: methanesulfonic acid / Cooling with ice

5: boron trifluoride diethyl etherate; dmap / 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

6: sodium methylate; methanol / 1 h

With hydrogenchloride; methanol; dmap; methanesulfonic acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium methylate; boron tribromide; sodium nitrite; In ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;

upstream raw materials:

1,2,3,4-tetrafluorobenzene

1,3-difluoro-2,4-dimethoxy-5-nitrobenzene

1-amino-3,5-difluoro-2,4-dimethoxybenzene

recorcinol

Refernces