N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester

Base Information

• Chemical Name: N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester
• CAS No.: 119543-19-0
• Molecular Formula: C₃₃H₃₈N₂O₅
• Molecular Weight: 542.675
• Mol file: 119543-19-0.mol

Synonyms:N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester

Chemical Property of N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester

There total 1 articles about N-[(2,3-Dihydro-1H-inden)-2-yl]-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]glycine phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,3-dihydro-1 H-inden-2-yl)-glycine benzyl ester hydrochloride (83356-18-7) + N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride (80828-26-8) → delapril benzyl ester (119543-19-0)

Guidance literature:

N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride; With hydrogenchloride; (chloromethylene)dimethyliminium chloride; In dichloromethane; at -10 - -5 ℃; for 0.5h; Inert atmosphere;

N-(2,3-dihydro-1 H-inden-2-yl)-glycine benzyl ester hydrochloride; With sodium hydrogencarbonate; In dichloromethane; water; Inert atmosphere;

Reference yield: 91.0%

delapril benzyl ester (119543-19-0) → delapril (83435-67-0,110508-92-4,110508-93-5,83435-66-9)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 15 - 20 ℃;

upstream raw materials:

N-(2,3-dihydro-1 H-inden-2-yl)-glycine benzyl ester hydrochloride

N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride

Downstream raw materials:

delapril

Refernces