Delapril hydrochloride

Base Information

• Chemical Name: Delapril hydrochloride
• CAS No.: 83435-67-0
• Deprecated CAS: 119543-18-9
• Molecular Formula: C26H32 N2 O5 . Cl H
• Molecular Weight: 489.011
• European Community (EC) Number: 801-621-7
• UNII: 2SMM3M5ZMH
• DSSTox Substance ID: DTXSID6048597
• Wikidata: Q27255552
• NCI Thesaurus Code: C72734
• ChEMBL ID: CHEMBL2106126
• Mol file: 83435-67-0.mol

Synonyms:CV 3317;CV-3317;delapril;derapril;N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)alanyl)glycine

Chemical Property of Delapril hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.67E-18mmHg at 25°C
• Melting Point: 169 ℃
• Boiling Point: 659.7ºC at 760 mmHg
• Flash Point: 352.7ºC
• PSA: 95.94000
• LogP: 3.80250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 12
• Exact Mass: 488.2077999
• Heavy Atom Count: 34
• Complexity: 649

Purity/Quality:

98%,99%, ^*data from raw suppliers

Delapril Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl
• Isomeric SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl
• Recent EU Clinical Trials: DOUBLE BLIND, RANDOMISED, PARALLEL GROUP, MULTICENTRE STUDY TO EVALUATE THE EFFECTS OF MANIDIPINE 20 MG VS AMLODIPINE 10 MG AND THE COMBINATION OF MANIDIPINE 10 MG PLUS DELAPRIL 30 MG VS AMLODIPINE 5 MG PLUS DELAPRIL 30 MG ON INTRAGLOMERULAR PRESSURE IN HYPERTENSIVE PATIENTS.
• Description: Delapril is a new angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential hypertension. Orally administered delapril is a prodrug which is de-esterified to its active diacid metabolite. In hypertensive patients delapril significantly decreased systolic blood pressure and ACE activity 24 hours after dosing without affecting endogeneous creatinine clearance.
• Uses: Delapril Hydrochloride is an angiotensin-converting-enzyme inhibitor (ACE) used as an antihypertensive drug in some European and Asian countries, but not in America.

Technology Process of Delapril hydrochloride

There total 11 articles about Delapril hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

delapril benzyl ester (119543-19-0) → delapril hydrochloride (83435-67-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium-carbon; In ethanol; ethyl acetate;

Reference yield: 91.0%

delapril benzyl ester (119543-19-0) → delapril (83435-67-0,110508-92-4,110508-93-5,83435-66-9)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 15 - 20 ℃;

Reference yield: 91.0%

N-(2,3-dihydro-1H-inden-2-yl)-N--L-alanyl>-glycine t-butyl ester (83435-61-4) → delapril hydrochloride (83435-67-0)

Guidance literature:

In ethyl acetate;

upstream raw materials:

N--L-alanyl>-N-(indan-2-yl)glycine

2-oxo-4-phenylbutanoic acid ethyl ester

tert-butyl N-(2,3-dihydro-1H-inden-2-yl)glycinate

N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester

Downstream raw materials:

Delaprilat

ethanol

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF DELAPRIL". Page/Page column 3. . Retrieved 2010/11/29.
• 2、 Miyake,Itoh,Oka. "Design and synthesis of N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-y l)glycine (CV-3317), a new, potent angiotensin converting enzyme inhibitor". . p. 2852 - 2858. Retrieved 2007/10/02.