Ethyl 2,4-difluoro-3-methoxybenzoylacetate

Base Information

Chemical Name:Ethyl 2,4-difluoro-3-methoxybenzoylacetate
CAS No.:221221-12-1
Molecular Formula:C12H12F2O4
Molecular Weight:258.222
Hs Code.:
DSSTox Substance ID:DTXSID101222468
Mol file:221221-12-1.mol

Synonyms:ethyl 2,4-difluoro-3-methoxybenzoylacetate;ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate;221221-12-1;SCHEMBL116517;TXHJJEPCDMOSGI-UHFFFAOYSA-N;DTXSID101222468;FT-0708816;Ethyl 2,4-difluoro-3-methoxy-beta-oxobenzenepropanoate;Ethyl-3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate

Suppliers and Price of Ethyl 2,4-difluoro-3-methoxybenzoylacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ethyl 2,4-difluoro-3-methoxybenzoylacetate

Chemical Property:

Boiling Point:322.3±37.0 °C(Predicted)
PKA:10.43±0.50(Predicted)
PSA：52.60000
Density:1.251±0.06 g/cm3(Predicted)
LogP:2.10930
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:258.07036518
Heavy Atom Count:18
Complexity:309

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C1=C(C(=C(C=C1)F)OC)F

Technology Process of Ethyl 2,4-difluoro-3-methoxybenzoylacetate

There total 3 articles about Ethyl 2,4-difluoro-3-methoxybenzoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 373603-19-1
2,4-difluoro-3-methoxyacetophenone

: 221221-12-1
ethyl 2,4-difluoro-3-methoxybenzoylacetate

: 656234-56-9
3-(2-ethoxy-4-fluoro-3-methoxyphenyl)-3-oxo-propionic acid ethyl ester

Guidance literature:: Diethyl carbonate; With sodium hydride; In toluene; at 90 ℃; for 1h;

2,4-difluoro-3-methoxyacetophenone; In toluene; at 85 - 95 ℃; for 0.5h;

Reference yield:

: 373603-19-1
2,4-difluoro-3-methoxyacetophenone

: 105-58-8,76619-83-5
Diethyl carbonate

: 221221-12-1
ethyl 2,4-difluoro-3-methoxybenzoylacetate

Guidance literature:: Diethyl carbonate; With sodium hydride; In toluene; mineral oil; at 90 ℃; Inert atmosphere;

2,4-difluoro-3-methoxyacetophenone; In toluene; mineral oil; at 90 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 373603-19-1
2,4-difluoro-3-methoxyacetophenone

: 105-58-8,76619-83-5
Diethyl carbonate

: 221221-12-1
ethyl 2,4-difluoro-3-methoxybenzoylacetate

: 656234-56-9
3-(2-ethoxy-4-fluoro-3-methoxyphenyl)-3-oxo-propionic acid ethyl ester

Guidance literature:: Diethyl carbonate; With sodium hydride; In toluene; at 90 ℃; for 1h;

2,4-difluoro-3-methoxyacetophenone; In toluene; at 90 - 95 ℃; for 0.5h;