2',4'-Difluoro-3'-methoxyacetophenone

Base Information

• Chemical Name: 2',4'-Difluoro-3'-methoxyacetophenone
• CAS No.: 373603-19-1
• Molecular Formula: C9H8F2O2
• Molecular Weight: 186.158
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID10397312
• Wikidata: Q72463131
• Mol file: 373603-19-1.mol

Synonyms:373603-19-1;2',4'-Difluoro-3'-methoxyacetophenone;1-(2,4-difluoro-3-methoxyphenyl)ethanone;2,4-Difluoro-3-methoxy acetophenone;2,4-Difluoro-3-methoxyacetophenone;1-(2,4-DIFLUORO-3-METHOXYPHENYL)ETHAN-1-ONE;SCHEMBL116280;DTXSID10397312;MFCD02258906;AKOS015956609;JS-4280;AC-10346;CS-0192184;FT-0739431;E89627;A924088;EN300-23320858

Chemical Property of 2',4'-Difluoro-3'-methoxyacetophenone

Chemical Property:

• Appearance/Colour: Colorless liquid
• Refractive Index: 1.4940
• Boiling Point: 246.3 °C at 760 mmHg
• Flash Point: 99.8 °C
• PSA: 26.30000
• Density: 1.213 g/cm³
• LogP: 2.17600
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 186.04923582
• Heavy Atom Count: 13
• Complexity: 196

Purity/Quality:

97% ^*data from raw suppliers

2',4'-Difluoro-3'-methoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C(=C(C=C1)F)OC)F

Technology Process of 2',4'-Difluoro-3'-methoxyacetophenone

There total 2 articles about 2',4'-Difluoro-3'-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H6F2O2 (951163-65-8) + dimethyl sulfate (77-78-1) → 2,4-difluoro-3-methoxyacetophenone (373603-19-1)

Guidance literature:

With potassium carbonate; In toluene; for 1h; Heating / reflux;

Reference yield:

dimethyl sulfate (77-78-1) → 2,4-difluoro-3-methoxyacetophenone (373603-19-1)

Guidance literature:

C₈H₆F₂O₂; With potassium carbonate; In toluene; for 2h; Heating / reflux;

dimethyl sulfate;

Reference yield:

2,4-difluoro-3-methoxyacetophenone (373603-19-1) → ethyl 2,4-difluoro-3-methoxybenzoylacetate (221221-12-1) + 3-(2-ethoxy-4-fluoro-3-methoxyphenyl)-3-oxo-propionic acid ethyl ester (656234-56-9)

Guidance literature:

Diethyl carbonate; With sodium hydride; In toluene; at 90 ℃; for 1h;

2,4-difluoro-3-methoxyacetophenone; In toluene; at 85 - 95 ℃; for 0.5h;

upstream raw materials:

dimethyl sulfate

C₈H₆F₂O₂

Downstream raw materials:

ethyl 2,4-difluoro-3-methoxybenzoylacetate

3-(2-ethoxy-4-fluoro-3-methoxyphenyl)-3-oxo-propionic acid ethyl ester

ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate

ethyl 2-(2,4-difluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate

Refernces

• 1、 -. "Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid". Page/Page column 8. . Retrieved 2008/06/13.