6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine

Base Information

• Chemical Name: 6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine
• CAS No.: 16031-94-0
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.318
• Mol file: 16031-94-0.mol

Synonyms:6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine

Chemical Property of 6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine

Chemical Property:

• PSA: 3.24000
• LogP: 3.16070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine

There total 3 articles about 6-Methyl-5,6,7,12-tetrahydrodibenz[c,f]azocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis/trans-2-Methyl-1-phenyl-2-<(trimethylsilyl)methyl>isoindolinium iodide → 6-Methyl-5,6,7,12-tetrahydrodibenzoazocine (16031-94-0) + 2-Methyl-1-phenylisoindoline (28504-96-3) + 1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline (28102-51-4,99087-42-0,109008-29-9)

Guidance literature:

With cesium fluoride; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 24h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00080a024

Reference yield:

cis/trans-2-Methyl-1-phenyl-2-<(trimethylsilyl)methyl>isoindolinium iodide → 6-Methyl-5,6,7,12-tetrahydrodibenzoazocine (16031-94-0) + 1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline (28102-51-4,99087-42-0,109008-29-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 10 ℃; for 3h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00080a024

Reference yield:

→ 6-Methyl-5,6,7,12-tetrahydrodibenzoazocine (16031-94-0)

Guidance literature:

2,2'-Bis-(brommethyl)-diphenylmethan, MeNH2;

DOI:10.1139/v73-504

Refernces