2-aMino-3-fluorobenzaldehyde

Base Information

• Chemical Name: 2-aMino-3-fluorobenzaldehyde
• CAS No.: 854538-94-6
• Molecular Formula: C7H6FNO
• Molecular Weight: 139.129
• Hs Code.: 2922390090
• Mol file: 854538-94-6.mol

Synonyms:2-aMino-3-fluorobenzaldehyde

Chemical Property of 2-aMino-3-fluorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.0444mmHg at 25°C
• Boiling Point: 237.6°C at 760 mmHg
• Flash Point: 97.5°C
• PSA: 43.09000
• Density: 1.293g/cm³
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-3-fluorobenzaldehyde is an intermediate used to prepare chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines as new N,P-ligands for asymmetric catalysis. It is also used to synthesize quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.

Technology Process of 2-aMino-3-fluorobenzaldehyde

There total 6 articles about 2-aMino-3-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C7H7ClFN → 2-amino-3-fluorobenzaldehyde (854538-94-6)

Guidance literature:

With ethanol; hexamethylenetetramine; at 27 ℃; for 7h; Temperature; Reflux; Large scale;

Reference yield: 55.0%

tert-butyl N-(2-formyl-6-fluorophenyl)carbamate (844891-30-1) → 2-amino-3-fluorobenzaldehyde (854538-94-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 3h;

DOI:10.1016/j.tetlet.2005.03.113

Reference yield:

(2-amino-3-fluorophenyl)methanol (906811-49-2) → 2-amino-3-fluorobenzaldehyde (854538-94-6)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

upstream raw materials:

tert-butyl N-(2-formyl-6-fluorophenyl)carbamate

tert-butyl 2-fluorophenylcarbamate

(2-amino-3-fluorophenyl)methanol

3-fluoroanthranilic acid

Downstream raw materials:

C₁₆H₁₆FN

8-fluoro-3-(2-(methylsulfinyl)phenyl)quinolin-2-amine

Refernces

• 1、 Sun, Huai-Ri,Zhao, Qingyang,Yang, Hui,Yang, Sen,Gou, Bo-Bo,Chen, Jie,Zhou, Ling. "Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization". supporting information. p. 7143 - 7148. Retrieved 2019/09/07.
• 2、 Ida, Yoshihiro,Matsubara, Ayaka,Nemoto, Toru,Saito, Manabu,Hirayama, Shigeto,Fujii, Hideaki,Nagase, Hiroshi. "Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands". . p. 5810 - 5831. Retrieved 2012/11/06.