R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol

Base Information

• Chemical Name: R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol
• CAS No.: 127912-58-7
• Molecular Formula: C₁₀H₁₄BrNO
• Molecular Weight: 244.131
• Mol file: 127912-58-7.mol

Synonyms:R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol;(R)-1-(6-Bromopyridin-2-yl)-2,2-dimethylpropan-1-ol

Chemical Property of R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol

There total 5 articles about R-6-broMo-α-(1,1-diMethylethyl)-2-PyridineMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one (127049-48-3) → (S)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol (127049-52-9) + (R)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropanol (127912-58-7)

Guidance literature:

With formic acid; triethylamine; RuCl(p-cymene)[N-(p-tosyl)-(1R,2R)-diphenylethylenediamine]; at 20 ℃; for 14h;

DOI:10.1055/s-2005-869983

Reference yield: 62.0%

1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one (127049-48-3) → (-)-isopinocampheol (1196-00-5) + (S)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol (127049-52-9) + (R)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropanol (127912-58-7) + 1-(6-chloropyridin-2-yl)-2,2-dimethylpropanol (139042-60-7)

Guidance literature:

With B-chlorodiisopinocampheylborane; Ambient temperature;

Reference yield:

1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one (127049-48-3) → (S)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol (127049-52-9) + (R)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropanol (127912-58-7) + 1-(6-chloropyridin-2-yl)-2,2-dimethylpropanone (139042-75-4) + 1-(6-chloropyridin-2-yl)-2,2-dimethylpropanol (139042-60-7)

Guidance literature:

With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at 10 ℃; for 21h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

Methyl pivalate

1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one

(rac)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol

Downstream raw materials:

(R)-2,2-dimethyl-1-(6-phenyl-pyridin-2-yl)propanol

(R,R)-6,6'-bis-(1-hydroxy-2,2-dimethylpropyl)-2,2'-bipyridine