4-Chloro-2-hydroxybenzamide

Base Information

• Chemical Name: 4-Chloro-2-hydroxybenzamide
• CAS No.: 37893-37-1
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2924299090
• European Community (EC) Number: 849-692-3
• DSSTox Substance ID: DTXSID90547752
• Wikidata: Q82426184
• Mol file: 37893-37-1.mol

Synonyms:4-chloro-2-hydroxybenzamide;37893-37-1;SCHEMBL1071711;DTXSID90547752;NXRFMWBOQWRGFW-UHFFFAOYSA-N;MFCD11130856;AKOS000207077;MB09408;AM803815;TS-02339;CS-0037776;EN300-57141;Z68591606

Chemical Property of 4-Chloro-2-hydroxybenzamide

Chemical Property:

• PSA: 64.31000
• LogP: 2.02870
• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 171.0087061
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)O)C(=O)N

Technology Process of 4-Chloro-2-hydroxybenzamide

There total 2 articles about 4-Chloro-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-2-methoxybenzamide (89978-92-7) → 2-hydroxy-4-chlorobenzamide (37893-37-1)

Guidance literature:

4-chloro-2-methoxybenzamide; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In dichloromethane; at 0 ℃;

Reference yield:

7-chloro-benzo[e][1,3]oxazine-2,4-dione (31544-40-8) → 2-hydroxy-4-chlorobenzamide (37893-37-1)

Guidance literature:

With potassium hydroxide;

Reference yield: 81.0%

2-hydroxy-4-chlorobenzamide (37893-37-1) + benzyl bromide (100-39-0) → 2-(benzyloxy)-4-chlorobenzamide (1134784-77-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

upstream raw materials:

7-chloro-benzo[e][1,3]oxazine-2,4-dione

4-chloro-2-methoxybenzamide

Downstream raw materials:

4-chloro-2-[(1-methyl-3-pyrrolidinyl)oxy]benzamide

N-(4-Chloro-2-hydroxy-benzoyl)-2-fluoro-benzamide

5-Chloro-2-[5-(2-fluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-phenol

5-(2-hydroxy-4-chlorobenzoyl)aminovaleric acid

Refernces