AV-45

Base Information

Chemical Name:AV-45
CAS No.:938435-69-9
Molecular Formula:C₂₀H₂₅FN₂O₃
Molecular Weight:360.429
Hs Code.:
Mol file:938435-69-9.mol

Synonyms:AV-45;Flobetair;4-[(1E)-2-[6-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methylbenzenamine;938435-69-9

Suppliers and Price of AV-45

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[(1E)-2-[6-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methyl-benzenamine
10mg
$ 1540.00

Total 8 raw suppliers

Chemical Property of AV-45

Chemical Property:

Boiling Point:524.7±50.0 °C(Predicted)
PKA:4.38±0.38(Predicted)
Density:1.162±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-[(1E)-2-[6-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methyl-benzenamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-[(1E)-2-[6-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methyl-benzenamine is studied in rat plasma and metabolism in liver microsomes. Also, it is used in the chemometric studies on brain-uptake of PET agents.

Technology Process of AV-45

There total 10 articles about AV-45 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₂₅H₃₃FN₂O₅

: 938435-69-9
(E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine

Guidance literature:: With hydrogenchloride; In water; dimethyl sulfoxide; at 20 ℃;
DOI:10.1080/00397911.2017.1404107

Reference yield: 73.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)aniline

: 938435-69-9
(E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine

Guidance literature:: formaldehyd; (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)aniline; With sodium methylate; In methanol; for 1.5h; Heating / reflux;

With sodium tetrahydroborate; In methanol; for 1h; Heating / reflux;

Reference yield:

: 17211-08-4
(4-bromo-benzyl)-phosphonic acid dimethyl ester

: 938435-69-9
(E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / toluene / 3 h / 20 °C

1.2: 6 h / 40 °C

2.1: sodium hydride / 1,4-dioxane / 3 h / 20 °C

2.2: Reflux

3.1: copper(ll) sulfate pentahydrate / ethanol / 105 °C / Sealed tube

4.1: ethanol / 4 h / 20 °C

5.1: copper(ll) sulfate pentahydrate; methanol / 12 h / 20 °C

6.1: dmap; triethylamine; sodium carbonate / dichloromethane / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 100 °C / Sealed tube

8.1: hydrogenchloride / dimethyl sulfoxide; water / 20 °C

With hydrogenchloride; methanol; dmap; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; 1.2: |Wittig-Horner Reaction;
DOI:10.1080/00397911.2017.1404107