Technology Process of 2-methoxy-5-(2-pyridinyl)Benzaldehyde
There total 1 articles about 2-methoxy-5-(2-pyridinyl)Benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / NaHCO3 / dimethylformamide / 14 h / 40 °C
2: 58 percent / NaOMe / methanol / 18 h / Heating
3: 82 percent / K2CO3 / acetone / 12 h / Heating
4: 97 percent / hydrogen / 10percent Pd/C / acetic acid / 24 h / 15001.2 Torr
With
hydrogen; sodium methylate; sodium hydrogencarbonate; potassium carbonate;
palladium on activated charcoal;
In
methanol; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1995-3993
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; water / 120 h / 20 °C / Inert atmosphere
2.1: 0.17 h / 180 °C / Inert atmosphere
3.1: trichlorophosphate / 1,2-dichloro-ethane / Inert atmosphere; Cooling with ice; Reflux
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / methanol / 15 h / Inert atmosphere; Reflux
6.1: sodium / Inert atmosphere
6.2: 2 h / 90 °C / 10 Torr / Inert atmosphere
7.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 18 h / 20 °C / 760.05 Torr / Darkness
8.1: toluene-4-sulfonic acid; oxygen / ethanol / 24 h / Darkness
9.1: dichloromethane
With
sodium tetrahydroborate; lithium hydroxide monohydrate; 5%-palladium/activated carbon; hydrogen; oxygen; sodium; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;
3.1: |Vilsmeier-Haack Formylation;
DOI:10.1021/acs.orglett.5b01306
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; water / 120 h / 20 °C / Inert atmosphere
2.1: 0.17 h / 180 °C / Inert atmosphere
3.1: trichlorophosphate / 1,2-dichloro-ethane / Inert atmosphere; Cooling with ice; Reflux
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / methanol / 15 h / Inert atmosphere; Reflux
6.1: sodium / Inert atmosphere
6.2: 2 h / 90 °C / 10 Torr / Inert atmosphere
7.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 18 h / 20 °C / 760.05 Torr / Darkness
8.1: toluene-4-sulfonic acid; oxygen / ethanol / 24 h / Darkness
9.1: dichloromethane
With
sodium tetrahydroborate; lithium hydroxide monohydrate; 5%-palladium/activated carbon; hydrogen; oxygen; sodium; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;
3.1: |Vilsmeier-Haack Formylation;
DOI:10.1021/acs.orglett.5b01306
