6096-81-7

Basic information

• Product Name: Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester
• CAS NO: 6096-81-7
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.158
• Mol File: 6096-81-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester(6096-81-7)
• EPA Substance Registry System: Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester(6096-81-7)

Safety Data

• Hazardous Substances Data: 6096-81-7(Hazardous Substances Data)

Usage

General Description

Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester is a chemical compound with the molecular formula C6H11NO4. It is an ester derivative of the amino acid glycine, with a methyl group replacing the hydrogen atom on the amino group. This chemical is commonly used as a building block in organic synthesis and is also used as a reagent in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It has a wide range of applications in the chemical and pharmaceutical industries, including as a precursor for the synthesis of various compounds and as a reagent in chemical reactions. Glycine, N-(2-methoxy-2-oxoethyl)-, methyl ester is also used as a research tool in biochemistry and can be found in various laboratory settings for experimental purposes.

Upstream product

• 67-56-1 methanol 
• 1116-43-4 methanediyldiimino-tetra-acetonitrile 
• 628-87-5 iminodiacetonitrile 
• 87218-68-6 dimethyl hydrazonobisacetate hydrochloride 
• 7732-18-5 water 
• 118104-63-5 dimethyl semicarbazidediacetate 
• 7782-77-6 cis-nitrous acid 
• 616-34-2 methoxycarbonylmethylamine 
• 7647-01-0 hydrogenchloride 
• 142-73-4 iminodiacetic acid 
• 6175-26-4 dimethyl 2,2′-(benzylazanediyl)diacetate 

Downstream Products

• 100958-37-0 indol-3-ylmethylimino-di-acetic acid dimethyl ester 
• 681033-92-1 chlorocarbonylimino-di-acetic acid dimethyl ester 
• 860749-91-3 tetrakis-methoxycarbonylmethyl-urea 
• 35855-08-4 dimethyl N-ethyliminodiacetate 
• 860541-29-3 cyanoimino-di-acetic acid dimethyl ester 
• 110998-31-7 (2-hydroxy-5-nitro-benzylimino)-di-acetic acid dimethyl ester 
• 55036-44-7 2,2',2,2'-(((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(azanetriyl))tetraacetic acid 
• 7372-13-6 N-(2-hydroxybenzyl)-N-(carboxymethyl)glycine 
• 21954-96-1 2,2′-iminobis(acetamide) 
• 5410-10-6 dimethyl 2,2'-(acetylazanediyl)diacetate 
• 69371-04-6 N,N'-diphenyl-2,2'-(2,5-dioxo-piperazine-1,4-diyl)-bis-acetamide 
• 1632-19-5 dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate 
• 109650-50-2 (phenylacetyl-imino)-di-acetic acid dimethyl ester 
• 31098-36-9 methacryloylimino-di-acetic acid dimethyl ester 

Relevant articles and documents

Gold nanoparticle-based probe for colorimetric detection of copper ions

A new ligand 10-mercaptodecyl-1-iminodiacetic acid (MDIA) was synthesized and used to modify gold nanoparticles to provide a simple assay to repeatedly sense Cu2+ in the solution at room temperature. This functionalized gold nanosensor was applied for the detection of Cu2+ in water samples with sensitivity and simplicity. The chelation/aggregation process is reversible via addition of a strong metal ion chelator such as EDTA. This simple and fast colorimetric sensor is important in the application of copper ion detection in water quality during the emergency and early warning monitoring.

Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester

Abstract: Heating glycine (Gly) and methyl glycinate (GlyOCH3) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180°C for 10 min. The deuterium atom inclusion under these conditions averaged up to 1.8 atoms per molecule for Gly and up to 1.0 atom per molecule for GlyOCH3. The reaction with tritium gas gave labeled products with a specific radioactivity of 27–31 Ci/mmol for Gly and 18 Ci/mmol for GlyOCH3.

Structure-activity relationships of imidazole-derived 2-[ N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

Insulin degrading enzyme (IDE) is a zinc metalloprotease that degrades small amyloid peptides such as amyloid-a and insulin. So far the dearth of IDE-specific pharmacological inhibitors impacts the understanding of its role in the physiopathology of Alzheimer's disease, amyloid-a clearance, and its validation as a potential therapeutic target. Hit 1 was previously discovered by high-throughput screening. Here we describe the structure-activity study, that required the synthesis of 48 analogues. We found that while the carboxylic acid, the imidazole and the tertiary amine were critical for activity, the methyl ester was successfully optimized to an amide or a 1,2,4-oxadiazole. Along with improving their activity, compounds were optimized for solubility, lipophilicity and stability in plasma and microsomes. The docking or co-crystallization of some compounds at the exosite or the catalytic site of IDE provided the structural basis for IDE inhibition. The pharmacokinetic properties of best compounds 44 and 46 were measured in vivo. As a result, 44 (BDM43079) and its methyl ester precursor 48 (BDM43124) are useful chemical probes for the exploration of IDE's role.