2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide

Base Information

• Chemical Name: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide
• CAS No.: 1083057-13-9
• Molecular Formula: C17H21NO3
• Molecular Weight: 285.343
• Mol file: 1083057-13-9.mol

Synonyms:2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide;2-(3-(tert-butoxycarbonyI)phenyl)-3-methylpyridine-1-oxide

Chemical Property of 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide

Chemical Property:

• Boiling Point: 472.7±33.0 °C(Predicted)
• PKA: 0.76±0.10(Predicted)
• PSA: 51.76000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 4.04580

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide

There total 5 articles about 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 3-(3-methylpyridin-2-yl)benzoate (1083057-12-8) → tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201805919

Reference yield: 95.0%

phthalic anhydride (85-44-9) + aqueous Na2SO3 + urea-hydrogen peroxide + tert-butyl 3-(3-methylpyridin-2-yl)benzoate (1083057-12-8) → tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9)

Guidance literature:

With sodium carbonate; In water; ethyl acetate;

Reference yield: 95.0%

phthalic anhydride (85-44-9) + tert-butyl 3-(3-methylpyridin-2-yl)benzoate (1083057-12-8) + urea hydrogen peroxide adduct (124-43-6) → tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9)

Guidance literature:

With sodium carbonate; In water; ethyl acetate;

upstream raw materials:

tert-butyl 3-(3-methylpyridin-2-yl)benzoate

phthalic anhydride

2-bromo-3-picoline

urea hydrogen peroxide adduct

Downstream raw materials:

tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate

Lumacaftor hydrochloride

Lumacaftor

tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate