3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester

Base Information

• Chemical Name: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
• CAS No.: 1083057-14-0
• Molecular Formula: C17H20N2O2
• Molecular Weight: 284.358
• Hs Code.: 2933399090
• Mol file: 1083057-14-0.mol

Synonyms:3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester; tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate

Chemical Property of 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester

Chemical Property:

• Boiling Point: 439.7±45.0 °C(Predicted)
• PKA: 5.95±0.34(Predicted)
• PSA: 65.94000
• Density: 1.119±0.06 g/cm3(Predicted)
• LogP: 3.52460
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl3-(6-amino-3-methylpyridin-2-yl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester

There total 6 articles about 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9) → tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate (1083057-14-0)

Guidance literature:

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate; With pyridine; Methanesulfonic anhydride; In acetonitrile; at 70 - 75 ℃; for 1.33333h;

With water; ethanolamine; In acetonitrile; at 10 - 20 ℃; for 5h;

Reference yield: 53.0%

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9) + ethanolamine (141-43-5) + Methanesulfonic anhydride (7143-01-3) → tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate (1083057-14-0)

Guidance literature:

With pyridine; In N₂; water; acetonitrile;

Reference yield: 53.0%

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate (1083057-13-9) + Methanesulfonic anhydride (7143-01-3) → tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate (1083057-14-0)

Guidance literature:

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate; With pyridine; In acetonitrile; at 70 ℃; Inert atmosphere;

Methanesulfonic anhydride; In acetonitrile; at 70 ℃; for 1.5h; Inert atmosphere;

With ethanolamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201805919

upstream raw materials:

tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate

ethanolamine

Methanesulfonic anhydride

2-bromo-3-picoline

Downstream raw materials:

tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate

Lumacaftor hydrochloride

Lumacaftor

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