2,7-Dichloro-1,5-naphthyridine

Base Information

Chemical Name:2,7-Dichloro-1,5-naphthyridine
CAS No.:28252-85-9
Molecular Formula:C8H4Cl2N2
Molecular Weight:199.039
Hs Code.:
DSSTox Substance ID:DTXSID201305324
Nikkaji Number:J99.585A
Mol file:28252-85-9.mol

Synonyms:2,7-dichloro-1,5-naphthyridine;28252-85-9;1,5-Naphthyridine, 2,7-dichloro-;SCHEMBL15551629;DTXSID201305324;2,7-Dichloro[1,5]naphthyridine #

Suppliers and Price of 2,7-Dichloro-1,5-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2,7-Dichloro-1,5-naphthyridine

Chemical Property:

PSA：25.78000
LogP:2.93660
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:197.9751535
Heavy Atom Count:12
Complexity:165

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC2=C1N=CC(=C2)Cl)Cl

Technology Process of 2,7-Dichloro-1,5-naphthyridine

There total 4 articles about 2,7-Dichloro-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959616-26-3
7-chloro-1,5-naphthyridin-2(1H)-one

: 28252-85-9
2,7-dichloro-1,5-naphthyridine

Guidance literature:: With trichlorophosphate; at 70 ℃; for 4h;

Reference yield:

: (E)-methyl 3-(3-amino-5-chloropyridin-2-yl)acrylate

: 28252-85-9
2,7-dichloro-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / ethanol / 3 h / Reflux

2: trichlorophosphate / 4 h / 70 °C

With sodium methylate; trichlorophosphate; In ethanol;

Reference yield:

: 90902-83-3
3-amino-2-bromo-5-chloropyridine

: 28252-85-9
2,7-dichloro-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 0.58 h / 145 °C / Microwave irradiation

2: sodium methylate / ethanol / 3 h / Reflux

3: trichlorophosphate / 4 h / 70 °C

With sodium methylate; triethylamine; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;