90902-83-3

Basic information

• Product Name: 3-AMINO-2-BROMO-5-CHLOROPYRIDINE
• Synonyms: 3-AMINO-2-BROMO-5-CHLOROPYRIDINE;2-BROMO-5-CHLOROPYRIDIN-3-AMINE;2-Bromo-3-Amino-5-Chloropyridine;2-BroMo-2-chloro-3-AMinopyridine
• CAS NO: 90902-83-3
• Molecular Formula: C₅H₄BrClN₂
• Molecular Weight: 207.45566
• Product Categories: Heterocycle-Pyridine series;Heterocyclic Acids,Indolines ,Indoles ,Indazoles;Amines;Pyridines;Pyridine;Heterocyclic Compounds
• Mol File: 90902-83-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 141-143°C
• Boiling Point: 312.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• Appearance: /
• Density: 1.834 g/cm³
• Vapor Pressure: 0.00052mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.54±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-2-BROMO-5-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-BROMO-5-CHLOROPYRIDINE(90902-83-3)
• EPA Substance Registry System: 3-AMINO-2-BROMO-5-CHLOROPYRIDINE(90902-83-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 90902-83-3(Hazardous Substances Data)

Usage

Uses

2-Bromo-5-chloro-3-pyridinamine is a reactant in the synthetic preparation of Chloro(chloromethyl)thiazolopyridine, a precursor of PC190723 (an antibacterial cell division inhibitor)

InChI:InChI=1/C5H4BrClN2/c6-5-4(8)1-3(7)2-9-5/h1-2H,8H2

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 21427-61-2 5-chloro-3-nitropyridin-2-ol 
• 75806-86-9 2-bromo-5-chloro-3-nitropyridine 

Downstream Products

• 1021339-19-4 6-chloro-1H-pyrrolo[3,2-b]pyridine 
• 159870-89-0 C₆H₂Cl₂N₂S 
• 1196153-99-7 6-chlorothiazolo[5,4-b]pyridin-2-amine 
• 1227588-49-9 3-bromo-5-chloropyridine-2-carbaldehyde 
• 28252-85-9 2,7-dichloro-1,5-naphthyridine 
• 959616-26-3 7-chloro-1,5-naphthyridin-2(1H)-one 
• 951122-66-0 2-(bromomethyl)-6-chloropyrido[3,2-d][1,3]thiazole 
• 951120-33-5 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide 
• 899424-36-3 N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-methyl-benzenesulfonamide 
• 899424-32-9 C₁₄H₁₄BrClN₂O₃S 
• 899422-52-7 N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-trifluoromethyl-benzenesulfonamide 
• 899424-34-1 N-(2-bromo-5-chloro-pyridin-3-yl)-3-trifluoromethyl-benzenesulfonamide 
• 899424-23-8 N-(2-bromo-5-chloro-pyridin-3-yl)-4-tert-butyl-benzenesulfonamide 
• 408538-29-4 3-amino-5-chloropicolinonitrile 

Relevant articles and documents

NaI/PPh3-Mediated Photochemical Reduction and Amination of Nitroarenes

A mild transition-metal- and photosensitizer-free photoredox system based on the combination of NaI and PPh3 was found to enable highly selective reduction of nitroarenes. This protocol tolerates a broad range of reducible functional groups such as halogen (Cl, Br, and even I), aldehyde, ketone, carboxyl, and cyano. Moreover, the photoredox catalysis with NaI and stoichiometric PPh3 provides also an alternative entry to Cadogan-type reductive amination when o-nitrobiarenes were used.

HETEROARYL SULFONAMIDES AND CCR2

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.