[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene

Base Information

• Chemical Name: [(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene
• CAS No.: 162157-05-3
• Molecular Formula: C₂₀H₁₉FeNO
• Molecular Weight: 345.224
• Mol file: 162157-05-3.mol

Synonyms:[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene

Chemical Property of [(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene

Chemical Property:

• PSA: 21.59000
• LogP: 1.77350

Purity/Quality:

97%, ^*data from raw suppliers

[(4S)-4,5-Dihydro-4-phenylmethyl-2-oxazolyl]ferrocene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene

There total 2 articles about [(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]-Ferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1-cyanoferrocene + L-Phenylalaninol (3182-95-4) → [(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-ferrocene (162157-05-3)

Guidance literature:

zinc(II) chloride; In chlorobenzene; N2-atmosphere; refluxing Fe-complex with slight excess of ligand and catalytic amt. of ZnCl2 for 72 h; treatment with brine, extn. into CH2Cl2, drying (MgSO4), evapn., chromy.(SiO2, hexane, ethyl acetate); elem. anal.;

DOI:10.1016/S0022-328X(97)00368-9

Reference yield:

ferrocenoyl chloride (1293-79-4) + L-Phenylalaninol (3182-95-4) → [(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-ferrocene (162157-05-3)

Guidance literature:

ferrocenoyl chloride; L-Phenylalaninol; With triethylamine; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

With triethylamine; p-toluenesulfonyl chloride; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo3011717

upstream raw materials:

L-Phenylalaninol

ferrocenoyl chloride