3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene

Base Information

• Chemical Name: 3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene
• CAS No.: 176672-06-3
• Molecular Formula: C16H13BrO2S
• Molecular Weight: 349.248
• Mol file: 176672-06-3.mol

Synonyms:3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene

Chemical Property of 3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene

Chemical Property:

• Melting Point: 83 - 85 °C
• PSA: 46.70000
• LogP: 5.34800
• Solubility.: DCM

Purity/Quality:

99% ^*data from raw suppliers

3-?Bromo-?6-?methoxy-?2-?(4-?methoxyphenyl)?benzo[b]thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene is an intermediate in the synthesis of nonsteroidal, selective estrogen receptor modulator (SERM), Raloxifene (R100000).

Technology Process of 3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene

There total 11 articles about 3-broMo-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3)

Guidance literature:

With bromine; In chloroform; at 60 ℃;

DOI:10.1021/jm970167b

Reference yield: 70.0%

(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane (1163701-10-7) → 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3)

Guidance literature:

With N-methylpyrrolidin-2-one hydrotribromide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/co500115b

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → [6-methoxy-3-[4-[2-(1-piperidinyl)ethoxy]-phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene oxalate salt (182133-44-4) + 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3)

Guidance literature:

With bromine; In chloroform;

upstream raw materials:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

para-iodoanisole

2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene

(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

Downstream raw materials:

2-(4-methoxyphenyl)-3-[N-(4-benzyloxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene

2-(4-methoxyphenyl)-3-(3-benzyloxyphenyl)-6-methoxybenzo[b]thiophene

(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

(E)-3-(4-(2-(1H-imidazol-4-yl)vinyl)phenoxy)-2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol

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