Acetamide, N-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-N-[4-(phenylmeth oxy)phenyl]-

Base Information

• Chemical Name: Acetamide, N-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-N-[4-(phenylmeth oxy)phenyl]-
• CAS No.: 189286-85-9
• Molecular Formula: C31H27NO4S
• Molecular Weight: 509.626
• Mol file: 189286-85-9.mol

Synonyms:

Chemical Property of Acetamide, N-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-N-[4-(phenylmeth oxy)phenyl]-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-N-[4-(phenylmeth oxy)phenyl]-

There total 3 articles about Acetamide, N-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-N-[4-(phenylmeth oxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

N-[4-(benzyloxy)phenyl]acetamide (41927-14-4) + 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → 2-(4-methoxyphenyl)-3-[N-(4-benzyloxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene (189286-85-9)

Guidance literature:

With 2,4,6-trimethyl-pyridine; copper(I) oxide; for 72h; Heating;

DOI:10.1021/jm970167b

Reference yield:

Cu2 O + N-[4-(benzyloxy)phenyl]acetamide (41927-14-4) + 3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → 2-(4-methoxyphenyl)-3-[N-(4-benzyloxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene (189286-85-9)

Guidance literature:

In 2,4,6-trimethyl-pyridine; ethyl acetate;

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 2-(4-methoxyphenyl)-3-[N-(4-benzyloxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene (189286-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Br₂ / CHCl₃ / 60 °C

2: 6 percent / Cu₂O, 2,4,6-collidine / 72 h / Heating

With 2,4,6-trimethyl-pyridine; copper(I) oxide; bromine; In chloroform;

DOI:10.1021/jm970167b

upstream raw materials:

N-[4-(benzyloxy)phenyl]acetamide

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Downstream raw materials:

2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene

2-(4-methoxyphenyl)-3-[N-(4-hydroxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene

Refernces

• 1、 Palkowitz, Alan D.,Glasebrook, Andrew L.,Thrasher, K. Jeff,Hauser, Kenneth L.,Short, Lorri L.,Phillips, D. Lynn,Muehl, Brian S.,Sato, Masahiko,Shetler, Pamela K.,Cullinan, George J.,Pell, Tina R.,Bryant, Henry U.. "Discovery and synthesis of [6-hydroxy-3-[4-[2-(1- piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]benzo[b]thiophene: A novel, highly potent, selective estrogen receptor modulator". . p. 1407 - 1417. Retrieved 2007/10/03.