tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate

Base Information

• Chemical Name: tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate
• CAS No.: 5249-68-3
• Molecular Formula: C21H30N2O7
• Molecular Weight: 422.47
• Mol file: 5249-68-3.mol

Synonyms:(4S)-4-(Benzyloxycarbonylamino)-5-[[(S)-2-methoxy-1-methyl-2-oxoethyl]amino]-5-oxopentanoic acid tert-butyl ester;tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate;Z-5-(tert-Butyloxy)-5-oxo-L-Nva-L-Ala-OMe

Chemical Property of tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate

Chemical Property:

• Melting Point: 97 - 98 °C
• PSA: 120.03000
• LogP: 2.86280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate

There total 9 articles about tert-Butyl 4-benzyloxycarbonylamino-N-(2-methoxy-1-methyl-2-oxoethyl)glutaramate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Z-Glu(OtBu)-Cl + L-alanine methyl ester hydrochloride (2491-20-5) → N-benzyloxycarbonyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester (5249-68-3)

Guidance literature:

With Indion 830S anion exchange resin; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1007/s10989-012-9337-5

Reference yield: 73.2%

L-alanine methyl ester hydrochloride (2491-20-5) + (S)-4-benzyloxycarbonylamino-4-fluorocarbonylbutyric acid tert-butyl ester (133010-26-1) → N-benzyloxycarbonyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester (5249-68-3)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Ambient temperature;

DOI:10.1021/jo00008a005

Reference yield:

N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutaminsaeure-pentachlor-phenyl-diester (6233-91-6) + L-alanine methyl ester hydrochloride (2491-20-5) → N-benzyloxycarbonyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester (5249-68-3)

Guidance literature:

With 2-Pyridone; triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00962a035

upstream raw materials:

N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutaminsaeure-pentachlor-phenyl-diester

L-alanine methyl ester hydrochloride

pentafluorophenyl N-benzyloxycarbonyl-γ-tert-butyl-L-glutamate

(S)-4-benzyloxycarbonylamino-4-fluorocarbonylbutyric acid tert-butyl ester

Downstream raw materials:

N-benzyloxycarbonyl-L-leucyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester

N-benzyloxycarbonyl-L-valyl-γ-tert-butyl-L-glutamyl-L-alanine methyl ester

N-Benzyloxycarbonyl-γ-tert.-butyl-L-glutamyl-L-alanin-hydrazid

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