4-(Benzyloxy)-3-fluoroaniline HCl

Base Information

• Chemical Name: 4-(Benzyloxy)-3-fluoroaniline HCl
• CAS No.: 76243-25-9
• Molecular Formula: C₁₃H₁₂FNO*ClH
• Molecular Weight: 253.704
• Mol file: 76243-25-9.mol

Synonyms:4-(Benzyloxy)-3-fluoroaniline HCl

Chemical Property of 4-(Benzyloxy)-3-fluoroaniline HCl

Chemical Property:

• PSA: 35.25000
• LogP: 4.37010

Purity/Quality:

98%min ^*data from raw suppliers

4-(Benzyloxy)-3-fluoroaniline hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Benzyloxy)-3-fluoroaniline HCl

There total 4 articles about 4-(Benzyloxy)-3-fluoroaniline HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

1-(benzyloxy)-2-fluoro-4-nitrobenzene (76243-24-8) → 4-(benzyloxy)-3-fluoroaniline hydrochloride (76243-25-9)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In ethanol; at 80 ℃; for 9h;

DOI:10.1016/j.bioorg.2021.105172

Reference yield:

1-(benzyloxy)-2-fluoro-4-nitrobenzene (76243-24-8) + ethereal hydrogen chloride + ethanol (64-17-5) → 4-(benzyloxy)-3-fluoroaniline hydrochloride (76243-25-9)

Guidance literature:

With sodium hydrogencarbonate; acetic acid; In water;

Reference yield:

2-fluoro-4-nitrophenol (403-19-0) → 4-(benzyloxy)-3-fluoroaniline hydrochloride (76243-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 0 °C

2: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 9 h / 80 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bioorg.2021.105172

upstream raw materials:

1-(benzyloxy)-2-fluoro-4-nitrobenzene

ethanol

2-fluoro-4-nitrophenol

benzyl bromide