3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE

Base Information

• Chemical Name: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE
• CAS No.: 191089-78-8
• Molecular Formula: C12H12FNO
• Molecular Weight: 205.232
• Mol file: 191089-78-8.mol

Synonyms:3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE;2-cyclohexen-1-one, 3-[(4-fluorophenyl)amino]-;3-((4-fluorophenyl)amino)cyclohex-2-enone;3-[(4-fluorophenyl)amino]-1-cyclohex-2-enone

Chemical Property of 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE

Chemical Property:

• PSA: 29.10000
• LogP: 2.94750

Purity/Quality:

98%min ^*data from raw suppliers

3-[(4-Fluorophenyl)amino]cyclohex-2-en-1-one ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE

There total 2 articles about 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-cylohexanedione (504-02-9) + 4-fluoroaniline (371-40-4) → 3-((4-fluorophenyl)amino)cyclohexyl-2-enone (191089-78-8)

Guidance literature:

With acetic acid; In toluene; at 110 ℃; for 4h;

DOI:10.1002/adsc.201601208

Reference yield: 83.0%

cyclohexane-1,2-dione (765-87-7) + 4-fluoroaniline (371-40-4) → 3-((4-fluorophenyl)amino)cyclohexyl-2-enone (191089-78-8)

Guidance literature:

at 140 ℃; for 0.333333h;

DOI:10.1002/(SICI)1097-458X(199705)35:5<311::AID-OMR94>3.0.CO;2-M

Reference yield: 89.0%

3-((4-fluorophenyl)amino)cyclohexyl-2-enone (191089-78-8) → 2-bromo-3-(4-fluorophenylamino)cyclohex-2-enone

Guidance literature:

With bromomalononitrile; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h; Reagent/catalyst;

DOI:10.1039/c3ra46687f

upstream raw materials:

cyclohexane-1,2-dione

4-fluoroaniline

1,3-cylohexanedione

Downstream raw materials:

2-amino-1-(4-fluorophenyl)-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-4-(1,3-diphenyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-1-(4-fluorophenyl)-5-oxo-4-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-1-(4-fluorophenyl)-5-oxo-4-(1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

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