Technology Process of 3-(3-(Methylsulfonyl)phenyl)piperidine
There total 18 articles about 3-(3-(Methylsulfonyl)phenyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; platinum(IV) oxide hydrate; hydrogen;
In
methanol; water;
at 20 ℃;
for 12h;
under 2585.81 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tert-butyl methyl ether; hexane / -28 °C / Inert atmosphere; Large scale
1.2: 8.5 h / -40 - -32 °C / Inert atmosphere; Large scale
2.1: tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium hydroxide / water; tetrahydrofuran / 4 - 66 °C / Inert atmosphere; Large scale
3.1: hydrogen; platinum on carbon / water; phosphoric acid / 18 h / 98 °C / 3102.97 Torr / Inert atmosphere; Autoclave; Large scale
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; platinum on carbon; tetrabutylammomium bromide; hydrogen; sodium hydroxide;
In
tetrahydrofuran; hexane; tert-butyl methyl ether; phosphoric acid; water;
2.1: |Suzuki Coupling;
DOI:10.1021/op025620u
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen; platinum on carbon / water; phosphoric acid / 18 h / 98 °C / 3102.97 Torr / Inert atmosphere; Autoclave; Large scale
2: methanol / 0.5 h / 70 °C / Inert atmosphere; Large scale
3: sodium hydroxide / water; dichloromethane / Inert atmosphere; Cooling; Large scale
With
platinum on carbon; hydrogen; sodium hydroxide;
In
methanol; dichloromethane; phosphoric acid; water;
DOI:10.1021/op025620u
