2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI)

Base Information

• Chemical Name: 2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI)
• CAS No.: 199680-90-5
• Molecular Formula: C₁₅H₁₄N₄O₄
• Molecular Weight: 314.301
• Mol file: 199680-90-5.mol

Synonyms:2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI)

Chemical Property of 2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI)

Chemical Property:

• Melting Point: 270 °C
• PSA: 112.26000
• LogP: 0.66150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI)

There total 3 articles about 2-Propenamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-3-(2-furanyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(E)-N-(6-Amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-acrylamide (199680-85-8) + methyl iodide (74-88-4) → (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-acrylamide (199680-90-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jm970515+

Reference yield:

5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione (146830-75-3) → (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-acrylamide (199680-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / EDC / methanol / 24 h / Ambient temperature

2: 68 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970515+

Reference yield:

3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1) → (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-acrylamide (199680-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / EDC / methanol / 24 h / Ambient temperature

2: 68 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970515+

upstream raw materials:

(E)-N-(6-Amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-acrylamide

methyl iodide

5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

3-(fur-2-yl)crotonic acid