(5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one

Base Information

• Chemical Name: (5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one
• CAS No.: 81154-00-9
• Molecular Formula: C₁₀H₆ClNOS₂
• Molecular Weight: 255.749
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID20360875
• Wikidata: Q82142884
• Mol file: 81154-00-9.mol

Synonyms:81154-00-9;(5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one;(5E)-5-[(2-Chlorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one;(E)-5-(2-Chlorobenzylidene)-2-mercaptothiazol-4(5H)-one;5-(2-CHLOROBENZYLIDENE)-2-THIOXO-1,3-THIAZOLIDIN-4-ONE;DTXSID20360875;AAIBSXUAGRXSIQ-VMPITWQZSA-N;MFCD04969006;AKOS000307451;AKOS000411098;(E)-5-(2-chlorobenzylidene)-2-thioxothiazolidin-4-one;F0459-0021;Thiazolidin-4-one, 5-(2-chlorobenzylidene)-2-thioxo-

Chemical Property of (5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one

Chemical Property:

• Vapor Pressure: 1.79E-06mmHg at 25°C
• Boiling Point: 395.8°C at 760 mmHg
• Flash Point: 193.2°C
• PSA: 93.53000
• Density: 1.54g/cm³
• LogP: 2.67570
• Storage Temp.: 2-8°C
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 254.9579339
• Heavy Atom Count: 15
• Complexity: 329

Purity/Quality:

98% ^*data from raw suppliers

(5E)-5-(2-Chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=C2C(=O)NC(=S)S2)Cl
• Isomeric SMILES: C1=CC=C(C(=C1)/C=C/2\C(=O)NC(=S)S2)Cl

Technology Process of (5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one

There total 4 articles about (5E)-5-(2-chlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-chloro-benzaldehyde (89-98-5) → (5Z)-5-(2-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (81154-08-7,81154-00-9)

Guidance literature:

With sodium acetate; In acetic acid; at 110 ℃; for 0.3h; Reagent/catalyst; Solvent; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.113

Reference yield: 94.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-chloro-benzaldehyde (89-98-5) → (E,Z)-5-(2-chlorophenylmethylene)-4-oxo-2-thioxothiazolidine (6318-36-1,81154-00-9)

Guidance literature:

With (2-hydroxyethyl)ammonium formate; at 20 ℃; for 0.0666667h; neat (no solvent);

DOI:10.1139/V10-011

Reference yield:

2-thioxo-4-thiazolidinone (141-84-4) + 2-chloro-benzaldehyde (89-98-5) → 5-(2-chlorobenzylidene)-rhodanine (81154-00-9)

Guidance literature:

With urea; In ethanol; for 5h; Reflux;

DOI:10.1016/j.bmc.2019.02.043

upstream raw materials:

2-thioxo-4-thiazolidinone

2-chloro-benzaldehyde