4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile
• CAS No.: 89853-27-0
• Molecular Formula: C₇H₈N₄S
• Molecular Weight: 180.233
• Hs Code.: 2933599590
• Mol file: 89853-27-0.mol

Synonyms:4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile;4-AMino-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile

Chemical Property of 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile

Chemical Property:

• PSA: 100.89000
• LogP: 1.54198

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-6-methyl-2-(methylsulfanyl)pyrimidine-5-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile

There total 3 articles about 4-Amino-6-methyl-2-(methylsulfanyl)-pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

S-methylisothiourea hemisulphate (147895-43-0) + (1-ethoxyethylidene)malononitrile (5417-82-3) → 4-amino-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile (89853-27-0)

Guidance literature:

S-methylisothiourea hemisulphate; (1-ethoxyethylidene)malononitrile; With sodium methylate; In methanol; at 0 - 20 ℃;

With water; In methanol; for 0.5h;

Reference yield: 74.0%

S-Methylisothiourea sulfate (867-44-7,147895-43-0) + (1-ethoxyethylidene)malononitrile (5417-82-3) → 4-amino-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile (89853-27-0)

Guidance literature:

With sodium methylate; In methanol; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2019.151312

Reference yield:

→ 4-amino-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile (89853-27-0)

Guidance literature:

Thioharnstoff, 1.) (Ethoxy-methyl-methylen)-malonsaeuredinitril, abs. A., NaOEt (1h, Kochen) (Bildung d. Na-Salzes), 2.) CH3I, W. (30 Min.);

DOI:10.1021/ja01506a038

upstream raw materials:

S-methylisothiourea hemisulphate

(1-ethoxyethylidene)malononitrile

S-Methylisothiourea sulfate

Downstream raw materials:

4-chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile

2-((3-amino-2,2-dimethylpropyl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

(R)-2-(piperidin-3-ylamino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one