Heptaethylene glycol di(p-toluenesulfonate)

Base Information

Chemical Name:Heptaethylene glycol di(p-toluenesulfonate)
CAS No.:69502-27-8
Molecular Formula:C28H42O12S2
Molecular Weight:634.766
Hs Code.:
DSSTox Substance ID:DTXSID50406639
Nikkaji Number:J302.959J
Wikidata:Q82211704
Mol file:69502-27-8.mol

Synonyms:69502-27-8;Heptaethylene glycol di(p-toluenesulfonate);Bis-Tos-PEG7;3,6,9,12,15,18-Hexaoxaicosane-1,20-diyl bis(4-methylbenzenesulfonate);2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;ST50759435;heptaethylene glycol ditosylate;SCHEMBL18613994;DTXSID50406639;MFCD06292255;AKOS002312539;BP-23429;WS-02065;HY-140368;CS-0114313;C70489;A923459;J-521425;3,6,9,12,15,18-Hexaoxaicosane-1,20-diylbis(4-methylbenzenesulfonate);20-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15,18-hexaoxaicosan-1-yl 4-methylbenzene-1-sulfonate

Suppliers and Price of Heptaethylene glycol di(p-toluenesulfonate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3,6,9,12,15,18-Hexaoxaicosane-1,20-diylbis(4-methylbenzenesulfonate) 98%
5g
$ 832.00

BroadPharm
Tos-PEG8-Tos 98%
500 MG
$ 320.00

Acrotein
Tos-PEG7-Tos 97%
0.5g
$ 366.70

Total 8 raw suppliers

Chemical Property of Heptaethylene glycol di(p-toluenesulfonate)

Chemical Property:

PSA：158.88000
LogP:4.67540
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:25
Exact Mass:634.21176912
Heavy Atom Count:42
Complexity:784

Purity/Quality:

97% ^*data from raw suppliers

3,6,9,12,15,18-Hexaoxaicosane-1,20-diylbis(4-methylbenzenesulfonate) 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)C2=CC=C(C=C2)C
Description Tos-PEG8-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of Heptaethylene glycol di(p-toluenesulfonate)

There total 5 articles about Heptaethylene glycol di(p-toluenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5617-32-3
heptaethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: 69502-27-8
2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Guidance literature:: With potassium hydroxide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2010.05.075

Reference yield: 96.0%

: 98-59-9
p-toluenesulfonyl chloride

: 105891-53-0
1-((2-(2-(2-(2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene

: 69502-27-8
2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Guidance literature:: 1-((2-(2-(2-(2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene; With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

p-toluenesulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1139/V06-093

Reference yield:

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 69502-27-8
2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 24 h

2: 97 percent / H₂ / Pd/C / CH₂Cl₂ / 48 h / 20 °C / 38000 Torr

3: 99 percent / Et₃N; KOH / tetrahydrofuran; H₂O / 7 h

With potassium hydroxide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 1: Etherification / 2: Hydrogenolysis / 3: Tosylation;
DOI:10.1021/jo990620m