1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane

Base Information

• Chemical Name: 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane
• CAS No.: 1243536-56-2
• Molecular Formula: C₁₄H₂₈N₆O₆
• Molecular Weight: 376.413
• Mol file: 1243536-56-2.mol

Synonyms:

Chemical Property of 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Bis-PEG6-azide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,20-Diazido-3,6,9,12,15,18-hexaoxaeicosane is an intermediate in the synthesis of O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]pentaethylene Glycol (A608865), a heterobifunctional polyethyleneglycol (PEG) derivative used in the preparation of intramolecular linking agents.

Technology Process of 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane

There total 2 articles about 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate (69502-27-8) → 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane (1243536-56-2,82055-94-5)

Guidance literature:

With sodium azide; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1016/j.bmc.2010.05.075

Reference yield:

→ 1,20-diazido-3,6,9,12,15,18-hexaoxaeicosane (1243536-56-2,82055-94-5)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 14h;

upstream raw materials:

2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate